Results 191 to 200 of about 24,287 (262)

ROS‐ATM‐CBP axis‐mediated PARP1 lactylation aggravates doxorubicin‐induced cardiotoxicity

Clinical and Translational Medicine, Volume 16, Issue 8, August 2026.
ROS function as signalling molecules to promote CBP‐mediated PARP1 lactylation in an ATM dependent manner, which induces PARP1 PARylation and ultimate cell apoptosis. CBP and SIRT1 as specific lactyltransferase and delactylase of PARP1. Lactylation of PARP1 depends on the LDHA activity and lactate production.
Wenbin Wang, Yingxian Sun
wiley   +1 more source

Wahnsinn in der taz

, 2019
openaire   +2 more sources

Hippo Pathway Regulation and Microenvironmental Cues Governing Human MSC Transition to Cancer‐Associated Fibroblasts

Journal of Cellular Physiology, Volume 241, Issue 8, August 2026.
ABSTRACT Cancer‐associated fibroblasts (CAFs) are key drivers of tumor progression. This study examined how three‐dimensional (3D) culture, hypoxia, and cancer‐derived soluble factors influence the transformation of human mesenchymal stem cells (hMSCs) into inflammatory CAFs (iCAFs). hMSCs from bone marrow, placenta, and chorion were cultured in 2D, in
Pimjai Chingsuwanrote, Chanchao Lorthongpanich, Pakpoom Kheolamai, Ting Gang Chew, Chuti Laowtammathron, Sudjit Luanpitpong, Rangsun Parnpai, Surapol Issaragrisil   +7 more
wiley   +1 more source

Novel Antibiotics and Emerging Resistance:&nbsp;<i>In Vitro</i>&nbsp;Activity of Five Antimicrobials Against Intensive Care Unit Isolates from a Turkish Tertiary Care Hospital. [PDF]

Infect Dis Clin Microbiol
Kutlu HH, Akdoğan-Kittana FN, Günaydın B, Özkılıç Y.   +3 more
europepmc   +1 more source

Cigarette Smoke‐Exposed Alveolar Epithelial Cell‐Derived Exosomes Exacerbate Skeletal Muscle Dysfunction Through HDAC2 Signalling

Journal of Cachexia, Sarcopenia and Muscle, Volume 17, Issue 4, August 2026.
ABSTRACT Background Skeletal muscle dysfunction (SMD) is a common extrapulmonary complication of chronic obstructive pulmonary disease (COPD). Histone deacetylase 2 (HDAC2) is closely involved in the suppression of inflammatory transcription and is progressively reduced during COPD progression.
Chao Li, MingZhi Ou, Gang Jiang, GuiXian Zheng, YongLiang Jiang   +4 more
wiley   +1 more source

Retraction Note: TAZ inhibition promotes IL-2-induced apoptosis of hepatocellular carcinoma cells by activating the JNK/F-actin/mitochondrial fission pathway. [PDF]

Cancer Cell Int
Ji K, Lin K, Wang Y, Du L, Xu C, He N, Wang J, Liu Y, Liu Q.   +8 more
europepmc   +1 more source

Small Extracellular Vesicle‐Derived Nidogen 1 Promotes HCC Carcinogenesis via Transglutaminase 3‐Mediated YAP/TAZ Signalling

Journal of Extracellular Vesicles, Volume 15, Issue 8, August 2026.
NID1‐rich sEVs released by HCC cells are internalized by recipient cells, where the C‐terminal region of NID1 binds to and stabilizes TGM3. This activates integrin‐FAK/Src/AKT and Hippo‐YAP/TAZ signalling, thereby promoting HCC proliferation, colony formation, migration, invasion, tumour growth, and lung metastasis.
Cherlie Lot Sum Yeung, Le Cui, Jingyi Wang, Ching‐Ping Chan, Tung Him Ng, Charlotte Jiaqi Lai, Xiaowen Mao, Sze Keong Tey, Michael Shing Yan Huen, Judy Wai Ping Yam   +9 more
wiley   +1 more source

MITF-Driven melanoma plasticity as a core mechanism of therapy resistance: integrating microenvironmental signaling, mechanotransduction, and metabolic reprogramming. [PDF]

Cell Cycle
Kisielewska M, Suwała S, Drąg-Zalesińska M, Rembiałkowska N.   +3 more
europepmc   +1 more source

Tumor Plasticity and Microenvironmental Crosstalk as Drivers of Metastasis and Therapy Resistance

MedComm, Volume 7, Issue 8, August 2026.
The graphical abstract is a schematic illustration of the bidirectional crosstalk between tumor plasticity and the tumor microenvironment (TME) in driving metastasis and therapy resistance. Tumor‐intrinsic factors such as genetic mutations and epigenetic reprogramming enable dynamic transitions between epithelial, mesenchymal, and cancer stem cell ...
Gunjan Dagar, Manisha Dagar, Ashna Gupta, Anju Surendranath, Suraja Kumar Das, Mohd Umar Rehmani, Mukesh Tanwar, Sameer Mirza, Muzafar A. Macha, Ammira S. Al‐Shabeeb Akil, Shahab Uddin, Mayank Singh, Ajaz A. Bhat   +12 more
wiley   +1 more source

Timing Mechanotransduction: Mechanically Dynamic Biomaterials Reveal the Temporal Hierarchy of YAP/TAZ Control Nodes. [PDF]

Adv Sci (Weinh)
Gandin A, Vanni G, Torresan V, Pelosin M, Busetto R, Citron A, Suli A, Contessotto P, Albanese C, Zanconato F, Panciera T, Piccolo S, Brusatin G.   +12 more
europepmc   +1 more source