Results 201 to 210 of about 104,199 (294)

Jianpi Jiedu Xiaozheng Fang Regulates Hepatocellular Carcinoma Proliferation and Metastasis Based on Network Pharmacology. [PDF]

J Cell Mol Med
Li B, Shi HQ, Luo R, Zhang ZQ, Dong XC, Li XH, Ye SQ, Zhong C.   +7 more
europepmc   +1 more source

Elevated TRIM25 Impairs Poly (ADP‐ribose) Metabolism via PARG Degradation and Mediates Compression‐Induced Intervertebral Disc Degeneration

Advanced Science, Volume 13, Issue 25, 4 May 2026.
TRIM25 acts as a multifunctional hub driving intervertebral disc degeneration under mechanical stress. Mechanical compression significantly upregulates TRIM25 expression, establishing it as a key E3 ubiquitin ligase platform. TRIM25 targets PARG and Ku80 via distinct molecular interfaces, triggering their ubiquitination and degradation.
Zhangrong Cheng, Haiyang Gao, Wenbo Wu, Pengzhi Shi, Xianglong Chen, Zimu Yu, Wang Wu, Kangcheng Zhao, Cao Yang, Yukun Zhang   +9 more
wiley   +1 more source

Nuclear Mechanotransduction Across the Metastatic Cascade: Decoding Spatiotemporal Heterogeneity in Cancer Dissemination

Advanced Science, Volume 13, Issue 25, 4 May 2026.
Tumor metastasis results from complex interactions between cancer cells and mechanical microenvironments. We propose a “nucleus‐centered, cross‐stage mechanical signal decoding” model, highlighting how nuclear mechanosensors interpret forces at different stages.
Linqi Song, Jingyang Liu, Xue Wang, Minpu Zhang, Changgang Sun   +4 more
wiley   +1 more source

Transcription factor NRF2 and the expression of the Hippo pathway effector TAZ in bladder tumorigenesis are significantly correlated. [PDF]

Discov Oncol
Vahabirad M, Ghasemi H, Pegah A, Goli Z, Tavilani H.   +4 more
europepmc   +1 more source

Neighborhood Crime and Non-Auto Mode Choice [PDF]

, 2008
Ferrell, Christopher, Mathur, Shishir, Mendoza, Emy   +2 more
core   +1 more source

Molecular Stratification of Antiphospholipid Syndrome Through Integrative Analysis of the Whole‐Blood RNA Transcriptome

Arthritis &Rheumatology, Volume 78, Issue 5, Page 1124-1133, May 2026.
Objective Antiphospholipid syndrome (APS) is a thromboinflammatory disorder characterized by clinical and mechanistic heterogeneity that complicates early diagnosis and hinders targeted treatment. We aimed to identify distinct molecular endotypes among antiphospholipid antibody (aPL)–positive patients using whole‐blood transcriptomics.
Amala Ambati, Feiyang Ma, Katarina Kmetova, Sherwin Navaz, Claire K. Hoy, Cyrus Sarosh, Ajay Tambralli, Erika Navarro‐Mendoza, Johann E. Gudjonsson, J. Michelle Kahlenberg, Jacqueline A. Madison, Alí Duarte‐García, Jason S. Knight, Yu Zuo   +13 more
wiley   +1 more source

The Stiff Side of Cancer: How Matrix Mechanics Rewrites Non-Coding RNA Expression Programs. [PDF]

Noncoding RNA
Campos-Parra AD, Puente-Rivera J, López-Camarillo C, Nuñez-Olvera SI, Hernández Nava N, Macias GA, Silva-Cázares MB.   +6 more
europepmc   +1 more source

Assessing Post‐Earthquake Emergency Healthcare Accessibility Considering Damage to Hospital Buildings and Transportation Infrastructure

Earthquake Spectra, Volume 42, Issue 2, May 2026.
This article presents a framework for performing a regional assessment of the accessibility of emergency healthcare facilities after a major earthquake. Accessibility is assessed by applying the enhanced two‐step floating catchment area method to a regional road network, implemented in ArcGIS.
Kiranjot Kaur, Carlos Molina Hutt, Amy M. Kim   +2 more
wiley   +1 more source

Uncovering the mechanism of arecoline's effect on oral submucous fibrosis: integrating transcriptomics and <i>in vitro</i> and <i>in vivo</i> experiments. [PDF]

Front Physiol
Liu Z, Yi J, Zeng F, Chen B, Ning W, Tang J, OuYang Y.   +6 more
europepmc   +1 more source

Macrophage‐Targeting Biomaterials for Osteoarthritis Therapy

Journal of Biomedical Materials Research Part A, Volume 114, Issue 5, May 2026.
Macrophage‐Targeting Biomaterials for Osteoarthritis Therapy. Created in BioRender. Jain, E. (2026) https://BioRender.com/x4f9o8g. ABSTRACT Osteoarthritis (OA) is a highly prevalent, disabling, and painful disease of the joints, characterized by progressive cartilage degeneration, synovial fibrosis, and pain.
Era Jain, Paul Nana Kwame Sagoe
wiley   +1 more source