Results 231 to 240 of about 24,287 (262)
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TAZ is important for maintenance of the integrity of podocytes
American Journal of Physiology-Renal Physiology, 2022Podocytes play an important role in maintaining the integrity of the structure and function of the kidney. We observed that mice with selective deletion of transcriptional coactivator with PDZ-binding motif (TAZ) in podocytes developed proteinuria. TAZ is constitutively active and critical for expression of synaptopodin, zonula occludens-1, and zonula
Jianchun Chen +3 more
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TAZ promotes PDX1-mediated insulinogenesis
Cellular and Molecular Life Sciences, 2022Transcriptional co-activator with PDZ-binding motif (TAZ) is a key mediator of the Hippo signaling pathway and regulates structural and functional homeostasis in various tissues. TAZ activation is associated with the development of pancreatic cancer in humans, but it is unclear whether TAZ directly affects the structure and function of the pancreas. So
Mi Gyeong Jeong +5 more
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Nature Reviews Cancer, 2018
Two papers recently published in Nature Medicine and Science Signaling highlight the various interdependent or independent ways by which YAP and TAZ can affect tumour growth.
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Two papers recently published in Nature Medicine and Science Signaling highlight the various interdependent or independent ways by which YAP and TAZ can affect tumour growth.
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YAP/TAZ phase separation for transcription
Nature Cell Biology, 2020YAP and TAZ, paralogous mammalian genes, act as the key transcriptional effectors of the Hippo pathway. Two recent reports show that both YAP and TAZ form liquid–liquid phase-separated bodies that promote gene transcription by engaging in super-enhancers.
J. Matthew Franklin, Kun-Liang Guan
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Distinct effects of Hippo-YAP/TAZ and YAP/TAZ-TEAD in epithelial maintenance and repair
Biochemical and Biophysical Research CommunicationsThe maintenance of epithelial homeostasis is essential for preserving tissue architecture and function, and the transcriptional co-activators YAP/TAZ are central to this regulatory network. Although the Hippo-YAP/TAZ-TEAD axis is known to govern epithelial integrity, it remains unclear to what extent Hippo-controlled YAP/TAZ activity overlaps with, or ...
Qiuyun Yuan +6 more
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Spindle localization of YAP/TAZ maintains even distribution of YAP/TAZ in daughter cells
Journal of BiosciencesYAP and TAZ are downstream effectors of the Hippo signaling pathway, known to shuttle between the cytoplasm and nucleus, where they primarily function as transcriptional coactivators. Although their nuclear role has been well characterized, the non-transcriptional functions of YAP/TAZ remain poorly understood.
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“Down the Taz River to the Home of Mameyev” (From the History of the Development of the Taz Bay)
Herald of Omsk University. Series: Historical studies, 2019The article first attempts to generalize information about the family of merchants and fish industrialists Mameyev, who lived on the coast of the Taz Bay in the second half of the 19th - first half of the 20th century. It is revealed that the first Mameyev settled there in 1863. In the late 19th century, along with other industrialists who set up their
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TAZ is indispensable for c-MYC-induced hepatocarcinogenesis
Journal of Hepatology, 2022Hong Wu, , Diego Francesco Calvisi
exaly