Results 191 to 200 of about 301,139 (233)

Influence of Diabetes Mellitus on the Development of Multidrug-Resistant Tuberculosis (MDR-TB) in Relation With Genetic Mutations of <i>M. tuberculosis</i> Isolates in Ethiopia. [PDF]

Can J Infect Dis Med Microbiol
Seid A, Nureddin S.
europepmc   +1 more source

Molecular Editing Reveals a Bilobalide Chemotype that Attenuates Prolyl Endopeptidase (PREP)‐Linked Neuroinflammation

Advanced Science, EarlyView.
Molecular editing of bilobalide uncovers BB56, a PREP‐engaging chemotype with enhanced anti‐inflammatory activity in microglia. Integrated CETSA‐MS, SAR, and pathway analyses link BB56 to attenuation of p38 MAPK/NF‐κB and NLRP3‐associated inflammatory signaling, highlighting bilobalide editing as a strategy for developing neuroinflammation‐modulating ...
Chanin Sillapachaiyaporn, Wenjing Wang, Yao Qin, Lili Yan, Stephan Scheeff, Xu He, Qiong Wu, Yue Lin, Jinsai Shang, Xin Ye, Jing Liu, Kailei Sun, Chun Wai Yeung, Junzhe Huang, Zhenghui Chen, Xiaodong Liu, Yiqun Geng, Shannon Wing Ngor Au, Bonaventure Y. Ip, Ho Ko, Billy Wai‐Lung Ng   +20 more
wiley   +1 more source

Settings, characteristics, and experiences of stigma among people with tuberculosis in Kenya: National survey results. [PDF]

PLOS Glob Public Health
Ronoh A, Limo J, Odeny L, Macharia S, Muinde R, Kiarie J, Ong'ang'o J, Mwirigi N, Nyaboke D, Kibuchi E, Kilonzo T, Wandia R, Mugambi-Nyaboga LN, Kathure I.   +13 more
europepmc   +1 more source

Fine‐Tuned Regulation of mRNA Translation and Transport by STAU2 Condensate Facilitates Neuronal Development and Plasticity

Advanced Science, EarlyView.
STAU2 undergoes phase separation to form dynamic condensates that package target mRNAs and deliver them to the distal ends of growing neuronal dendrites. STAU2 condensates stabilize embedded mRNAs and repress their translation. Synaptic activity bidirectionally remodels STAU2 condensates, coordinating local translation of STAU2‐associated mRNAs ...
Shijing Huang, Yuanyuan Chu, Ruiqian Zhao, Siyu Li, Yu Feng, Hongdan Zheng, Yunli Xie, Tong Wang, Wenyu Wen   +8 more
wiley   +1 more source

A Year in Review on Tuberculosis and Non-tuberculous Mycobacteria Disease: A 2026 Update for Clinicians and Scientists. [PDF]

Pathog Immun
Tunesi S, Bothamley G, Günther G, Kherabi Y, Kuksa L, Lange B, Lange C, Lorent N, Saluzzo F, Sester M, Iversen XES, Tebruegge M, Tweed C, Vasiliu A, Guglielmetti L, Tuberculosis Network European Trials group (TBnet).   +15 more
europepmc   +1 more source

Dynamic Regulation of Endogenous Transcription Factor Hubs at Single‐Molecule Resolution

Advanced Science, EarlyView.
This study combines single‐molecule microscopy and genome editing to characterize the dynamic behaviors of endogenous oncofusion transcription factor EWS::FLI1 in Ewing sarcoma cells. EWS::FLI1 forms neomorphic hubs that dynamically assemble and dissolve. The hubs are regulated during mitosis, by RNA, and by specific chemicals.
Shawn Yoshida, Yanghao Zhong, Akiko Kumagai, William G. Dunphy, Shasha Chong   +4 more
wiley   +1 more source

The microbiological diagnosis of pediatric tuberculosis: focus on the Ultra test. [PDF]

J Bras Pneumol
Battaglia CSP, Aurilio RB, Pinheiro MA, Parente AAAI, Luiz RR, Sant Anna CC, Sant Anna MFBP.   +6 more
europepmc   +1 more source

Stage‐Adaptive Janus Microneedle System for Redox‐Immune Regulation and Mitochondrial Protection in Infected Diabetic Wound Healing

Advanced Science, EarlyView.
ABSTRACT Infected diabetic wounds are sustained by a vicious cycle of hyperglycemia‐driven bacterial infection, persistent oxidative stress, and excessive inflammation, which collectively disrupt the ordered progression of tissue repair. Here, we engineered a stage‐adaptive Janus microneedle patch (MN‐FeSAC‐PPE) to enable a staged therapeutic process ...
Mengting Yin, Yu Zhang, Xinyu Qu, Jiayi Liu, Zhongyi Sun, Haibo Liu, Ziyan Chen, Jing Ru, Jingwen Han, Bingqiang Lu, Yan Lu, Yan Wang, Xinyu Zhao, Feng Chen   +13 more
wiley   +1 more source

National TB cohort review evaluation: insights for control strategies in low-incidence settings. [PDF]

IJTLD Open
Barry TD, Underwood J, Backx M, Brouns M, Story A, Lowe G, Weeks L, Hester Y, Lloyd P, Bunce R, Johnstone L, Pallmann P, Thomas-Jones E, Murray N, Jones K, Thomas DR, Ahern G, Metters K, Smith J, Barry SM.   +19 more
europepmc   +1 more source

Senescent Cell Derived Artificial Vesicle‐Based Senolytic Sonovaccine Platform with Augmented Lymph Node Delivery and Antigen Cross‐Presentation Efficacy

Advanced Science, EarlyView.
A senolytic sonovaccine platform (SenoVac) is developed, in which senescent cell‐derived vesicles serve as broad senescent cell antigen reservior. The “2‐step” click chemistry strategy for effective lymph node delivery, and ultrasound‐triggered endosomal escape to boost cross‐presentation, ensures efficient senescent cell clearance and disease ...
Liang Zhang, Yubo Lai, Jia Wang, Lingling Liu, Jieyuan An, Mi Qu, Yuan Liang, Bijun Tan, Guodong Yang, Xuekang Yang, Lijun Yuan   +10 more
wiley   +1 more source