Results 91 to 100 of about 37,775 (207)

The ciliary neurotrophic factor induces Stat3 phosphorylation in distinctive cytotypes of organs involved in body metabolism: An immunohistochemical study

Journal of Anatomy, EarlyView.
p‐STAT3‐positive cells in metabolically relevant peripheral organs and tissues from mice administered with recombinant CNTF (0.3 mg/kg). Abstract Administration of ciliary neurotrophic factor (CNTF) reduces food intake and body weight in both humans and experimental animals, where it also ameliorates hyperglycemia, hyperinsulinemia, and dyslipidemia ...
Chiara Galli, Georgia Colleluori, Jessica Perugini, Edoardo Scopini, Ilenia Severi, Gaia Grandin, Antonio Giordano   +6 more
wiley   +1 more source

Study on purification， structural characterization， and antioxidant activity of Scenedesmus polysaccharides

Siliao yanjiu
The experiment aimed to explore the purification, structural characterization, and antioxidant activity of polysaccharides from Scenedesmus. Two rounds of column chromatography were conducted to purify the crude polysaccharides from Scenedesmus, and the ...
WANG Chuanlin, LIU Haowen, LIU Jiaxuan, LIU Pinghuai   +3 more
doaj  

2,4,6-Tribromophenol inhibits neural differentiation of mESCs by disrupting lipid metabolism and mitochondrial function

Ecotoxicology and Environmental Safety
2,4,6-Tribromophenol (TBP) is the most environmentally prevalent bromophenol pollutant. Although TBP tends to accumulate in the brain, its neurotoxic effects and underlying mechanisms remain poorly understood. In the present study, the neurodevelopmental
Yumiao Sun, Yao Pei, Huinan Liu, Yurou Gao, Xiaoxi Yang, Qian S. Liu, Li Xu, Francesco Faiola, Qunfang Zhou, Guibin Jiang   +9 more
doaj   +1 more source

Fluvastatin Plus Dipyridamole Suppresses Canine Hemangiosarcoma Growth in Patient‐Derived Xenograft Models Through Lactate Dehydrogenase‐Associated Cholesterol/Lipid Metabolism

Veterinary and Comparative Oncology, EarlyView.
ABSTRACT Tumour cells commonly exhibit aerobic glycolysis and produce lactate despite oxygen availability. Lactate dehydrogenase (LDH) catalyses pyruvate‐lactate interconversion and regulates intracellular lactate levels. Endothelial cells also depend on glycolysis for ATP production, which prompted us to investigate LDH in canine hemangiosarcoma (HSA),
Tamami Suzuki, Suzune Tanaka, Keika Kishimoto, Takuma Goto, Jumpei Yamazaki, Takashi Kimura, Keisuke Aoshima   +6 more
wiley   +1 more source

Targeting Transcription Through Inhibition of TBP

Oncotarget, 2011
Thaddeus T. Schug * National Institute of Environmental Health Sciences, Division of Extramural Research and Training, Cellular, Organ and Systems Pathobiology Branch, Research Triangle Park, NC 27709, USA Received: February 28, 2011; Accepted: March 1, 2011; Published: March 1, 2011; Correspondence: Thaddeus T. Schug, e-mail: //
openaire   +3 more sources

The impact of microplastics on the adsorption of 2,4,6-tribromophenol in soils: Competitive adsorption

Ecotoxicology and Environmental Safety
Soil is a major sink for microplastics (MPs) which can interact with organic contaminants affecting their transport behavior. The impact of MPs in soil matrix is complicated depending on soil-MPs, soil-contaminants and MPs-contaminants interactions ...
Guoyu Ding, Yuxin Wei, Yuqiao Fan, Mengmeng Dou, Miao Li, Xiang Liu, Jin Wang, Yanmei Zhou   +7 more
doaj   +1 more source

Δ9 Tetrahydrocannabinol and cannabis extracts differentially improve adipoinsular dysfunction in diet‐induced obesity

The Journal of Physiology, EarlyView.
Abstract figure legend THC and extract administered to diet‐induced obese mice reduced body weight and fat storage. Extract, but not THC, improved glucose clearance by a mechanism that may include restoring adipoinsular function. Abstract Diet‐induced obesity (DIO) is associated with dysregulated adipoinsular axis and endocannabinoid system (eCBS ...
Bryant Avalos, Martin Olmos, Courtney P. Wood, Camila Alvarez, Haley M. Read, Parima Udompholkul, Theodore Garland Jr, Nicholas V. DiPatrizio   +7 more
wiley   +1 more source

Electrolyte Solvation Chemistry and Systemic Safety in Potassium‐Ion Batteries

Small Structures, Volume 7, Issue 11, November 2026.
Electrolyte solvation chemistry determines the interphase that governs potassium‐ion battery performance, regardless of whether the electrode or the electrolyte is the focus of design. This review separates studies that engineer the solvation structure from those that adopt an electrolyte without examining it, and shows that thermal safety is an ...
Chase L. Clements, Vilas G. Pol
wiley   +1 more source

Decoding neuronal vulnerability: Multidimensional analysis of D1R‐ and D2R‐ medium‐sized spiny neurons in Huntington's disease

Brain Pathology, Volume 36, Issue 6, November 2026.
D1R and D2R MSNs show distinct responses to Huntington's pathology. G&T‐sequencing of pre‐symptomatic MSNs reveals global LINE‐1 downregulation. While D1R‐MSNs display early transcriptomic changes (OXPHOS/translation upregulation) and reduced mutant huntingtin aggregation, D2R‐MSNs exhibit higher nuclear mHTT accumulation and greater CAG somatic ...
Guendalina Bergonzoni, Miguel Pellegrini, Aurora Savino, Martina Lazioli, Sarah Geurs, Lorenzo Graziani, Denise Ferrarini, Solaleh Khoramian Tusi, Esaria Oliver, Jarne Geurts, Sara Vinciguerra, Michele Tebaldi, Takshashila Tripathi, Isabella Pesce, Valeria Poli, Alessandro Romanel, Rosario Moratalla, Thierry Voet, Jasmin Morandell, Remo Sanges, Vanessa C. Wheeler, Erik Dassi, Marta Biagioli   +22 more
wiley   +1 more source

Optimising Melanoma Diagnostic Accuracy in Specialised Pigmented Lesion Clinics: A Five‐Year Audit of Number Needed to Treat

Australasian Journal of Dermatology, EarlyView.
C. Ramirez, M. A. El Sharouni, L. Clavero‐Rovira, B. Gallo, B. Gouveia, C. Sinz, S. Kapila, A. Glanz, H. Collgros, A. E. Cust, L. K. Martin, P. Guitera   +11 more
wiley   +1 more source