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The emerging role and targetability of the TCA cycle in cancer metabolism
Protein and Cell, 2017 The tricarboxylic acid (TCA) cycle is a central route for oxidative phosphorylation in cells, and fulfills their bioenergetic, biosynthetic, and redox balance requirements.
Nicole Anderson, Hui Feng
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RNA Biology, 2023 The tricarboxylic acid (TCA) cycle is a central route for generating cellular energy and precursors for biosynthetic pathways. Emerging evidences have shown that the aberrations of metabolic enzymes which affect the integrity of TCA cycle are implicated ...
Tao Shen, Xiangting Wang
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Pathway classification of TCA cycle
IEE Proceedings - Systems Biology, 2006The structural analysis of large metabolic networks exhibits a combinatorial explosion of elementary modes. A new method of classification has been developed [called aggregation around common motif (ACoM)], which groups elementary modes into classes with similar substructures.
Pérès, S. +2 more
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Regulation of the urea cycle and TCA cycle by ammonia
Advances in Enzyme Regulation, 1966Abstract This paper presents the biochemical and enzymatic fundamentals of ammonia toxicity and automatic regulation of urea formation from ammonia. 1. 1.It is considered that the oxidation of isocitrate to 2-oxoglutarate is more sensitive to ammonia than the other dehydrogenases in the TCA cycle. 2.
N, Katunuma, M, Okada, Y, Nishii
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The TCA cycle as a bridge between oncometabolism and DNA transactions in cancer [PDF]
Seminars in Cancer Biology, 2017 Cancer cells exploit metabolic rearrangements for sustaining their high proliferation rate and energy demand. The TCA cycle is a central metabolic hub necessary for ATP production and for providing precursors used in many biosynthetic pathways.
Luca di Leo +2 more
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Boosted TCA cycle enhances survival of zebrafish to Vibrio alginolyticus infection
Virulence, 2018 Vibrio alginolyticus is a waterborne pathogen that infects a wide variety of hosts including fish and human, and the outbreak of this pathogen can cause a huge economic loss in aquaculture.
Xuanxian Peng, Manjun Yang, Bo Peng
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The functional roles of TCA cycle metabolites in cancer
Oncogene, 2021The tricarboxylic acid cycle (TCA cycle) has been known for decades as a hub for generating cellular energy and precursors for biosynthetic pathways. Several cancers harbor mutations that affect the integrity of this cycle, mostly at the levels of isocitrate dehydrogenase (IDH), succinate dehydrogenase (SDH), and fumarate hydratase (FH).
Joseph Eniafe, Shuai Jiang
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TCA cycle off, ATF4 on for metabolic homeostasis
Trends in Biochemical Sciences, 2022Tricarboxylic acid (TCA) cycle is a major hub for catabolic and anabolic reactions, yet cellular metabolic adaptations following its inhibition are largely unknown. Using multi-tiered omics approaches, Ryan et al. have shown convergent activation of the integrated stress response (ISR) through ATF4-mediated rewiring of cellular amino acid and redox ...
Durga Mahor +2 more
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Phosphatases are involved in modulating the TCA cycle in plants
Molecular Plant, 2021Abstract Phosphorylation is a reversible posttranslational modification that modulates the activities of numerous proteins. In plants, it is known that several mitochondrial proteins can be phosphorylated, including enzymes of the TCA cycle. The kinases and phosphorylases that mediate reversible phosphorylation of TCA cycle enzymes are largely ...
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Mitochondrial engineering of the TCA cycle for fumarate production
Metabolic Engineering, 2015Microbial fumarate production from renewable feedstock is a promising and sustainable alternative to petroleum-based chemical synthesis. Here, mitochondrial engineering was used to construct the oxidative pathway for fumarate production starting from the TCA cycle intermediate α-ketoglutarate in Candida glabrata.
Xiulai, Chen +4 more
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