Results 11 to 20 of about 46,097 (206)

Critical role of TCF-1 in repression of the IL-17 gene. [PDF]

PLoS ONE, 2011
Overwhelming activation of IL-17, a gene involved in inflammation, leads to exaggerated Th17 responses associated with numerous autoimmune conditions, such as experimental autoimmune encephalomyelitis (EAE).
Jian Ma, Ruiqing Wang, Xianfeng Fang, Yan Ding, Zuoming Sun   +4 more
doaj   +2 more sources

Strong negation in the theory of computable functionals TCF [PDF]

Logical Methods in Computer Science
We incorporate strong negation in the theory of computable functionals TCF, a common extension of Plotkin's PCF and G\"{o}del's system $\mathbf{T}$, by defining simultaneously strong negation $A^{\mathbf{N}}$ of a formula $A$ and strong negation $P^{
Nils Köpp, Iosif Petrakis
doaj   +3 more sources

Long Wavelength TCF-Based Fluorescent Probe for the Detection of Alkaline Phosphatase in Live Cells [PDF]

Frontiers in Chemistry, 2019
A long wavelength TCF-based fluorescent probe (TCF-ALP) was developed for the detection of alkaline phosphatase (ALP). ALP-mediated hydrolysis of the phosphate group of TCF-ALP resulted in a significant fluorescence “turn on” (58-fold), which was ...
Lauren Gwynne, Adam C. Sedgwick, Jordan E. Gardiner, George T. Williams, Gyoungmi Kim, John P. Lowe, Jean-Yves Maillard, A. Toby A. Jenkins, Steven D. Bull, Jonathan L. Sessler, Juyoung Yoon, Tony D. James   +11 more
doaj   +2 more sources

Nicotinamide Metabolism Constrains Memory CD8⁺ T Cell Formation Through a Putative HS1BP3-SIRT1-FOXO3-BCL6 Axis. [PDF]

Adv Sci (Weinh)
ABSTRACT Memory T cells exhibit long‐term persistence, a defining feature that underpins durable clinical responses to adoptive immunotherapies. The mechanisms that integrate metabolic cues with transcriptional control of memory fate remain undetermined. Here, we identify HS1‐binding protein 3 (HS1BP3) is preferentially expressed in memory CD8+ T cells.
Wang S, Fan X, Huang Y, Yao C, Fan J, Ping Y, Zhao X, Li C, Shen C, Shan J, Liu J, Wang S, Zhang Z, Zhang Y.   +13 more
europepmc   +2 more sources

TCF-1 limits intraepithelial lymphocyte antitumor immunity in colorectal carcinoma

, 2023
Intraepithelial lymphocytes (IELs), including αβ and γδ T cells (T-IELs), constantly survey and play a critical role in maintaining the gastrointestinal epithelium.
Maxine Smith (18223241), Simone Ostrouska (9498830), Marina Yakou (11910443), Amr Allam (9493064), Jordan Wilcox (11216838), Kevin Schmid (13192484), Gabrielle T Belz (14529650), Pavitha Parathan (9498905), Shoukat Afshar-Sterle (20800286), Hai-Hui Xue (803109), John Mariadason (9487703), Roland Ruscher (5247032), Dinesh Raghu (9493037), Bhupinder Pal (9493058), Kelly Tran (9474833), Anita Narendra KUMARI (11649598), David Williams (9477638), Christine Dijkstra (4021493), Andreas Behren (9477650), Lisa Mielke (9493028), Grant Drummond (9477542), Wei Shi (9483452), Sonia Ghilas (10012037), Matthias Ernst (9487700), Yang Liao (9001520), Chantelle Inguanti (18055261)   +25 more
core   +2 more sources

Characterization of TCF‐1 and its relationship between CD8+ TIL densities and immune checkpoints and their joint influences on prognoses of lung adenocarcinoma patients

Thoracic Cancer, 2023
Background T cell factor‐1 (TCF‐1) + stem‐like tumor‐infiltrating lymphocytes (stem‐like TILs) are important memory cells in the tumor microenvironment. However, their relationship with clinicopathological features, CD8+ TIL densities, immune checkpoint ...
Kanqiu Jiang, Shasha Liu, Yongbing Chen, Zhonghen Xu, Zhonghua Xu, Bo Qian, Qifeng Ding, Hongxia Cui, Yiqun Sui, Defu Cao, Weihua Xu, Mingjing Shen   +11 more
doaj   +1 more source

TPL-2 inhibits IFN-β expression via an ERK1/2-TCF-FOS axis in TLR4-stimulated macrophages.

, 2022
TPL-2 kinase plays an important role in innate immunity, activating ERK1/2 MAPKs in myeloid cells following TLR stimulation. We investigated how TPL-2 controls transcription in TLR4-stimulated mouse macrophages.
Erwin F Wagner (7953668), Louise Blair (12059531), Stamatia Papoutsopoulou (3143898), Steven C Ley (9131366), Probir Chakravarty (755948), Latifa Bakiri (270913), Stephen Smale (6113156), Michael J Pattison (9264929)   +7 more
core   +1 more source

The Impact of High-mobility Group Box Mutation of T-cell Factor 4 on Its Genomic Binding Pattern in Non–small Cell Lung Cancer

Translational Oncology, 2020
T-cell factor 4 (TCF-4) is determined to play a crucial role in Wnt/β-catenin signaling pathway activation. The mutations and alternative splice isoforms of TCF-4 can cause cancers and other diseases.
Hongjian Su, Yahong Qiao, Zhuona Xi, Jifang Wang, Zhen Bao   +4 more
doaj   +1 more source

Strong negation in the theory of computable functionals TCF [PDF]

, 2023
We incorporate strong negation in the theory of computable functionals TCF, a common extension of Plotkin's PCF and G\"{o}del's system $\mathbf{T}$, by defining simultaneously the strong negation $A^{\mathbf{N}}$ of a formula $A$ and the strong negation $
Köpp, Nils, Petrakis, Iosif
core   +1 more source

Wnt/beta-catenin/Tcf signaling: A critical pathway in gastrointestinal tumorigenesis [PDF]

, 2002
Cancers of the gastrointestinal tract, including the liver, bile ducts, and pancreas, constitute the largest group of malignant tumors. Colorectal cancer is one of the most common neoplastic diseases in Western countries and one of the leading causes of ...
Bommer, G., Göke, Burkhard, Göke, B., Kolligs, Frank T, Bommer, Guido, Kolligs, F. T.   +5 more
core   +1 more source