Results 31 to 40 of about 46,097 (206)
TCF 4 tumor suppressor: a molecular target in the prognosis of sporadic colorectal cancer in humans
Cellular & Molecular Biology Letters, 2020 Background A huge array of function is played by the Wnt/β-catenin signaling pathway in development by balancing gene expression through the modulation of cell-specific DNA binding downstream effectors such as T-cell factor/lymphoid enhancer factor (TCF ...
Mumtaz Anwar +6 more
doaj +1 more source
Cells, 2023 Canonical Wnt signaling is essential for a plethora of biological processes ranging from early embryogenesis to aging. Malfunctions of this crucial signaling pathway are associated with various developmental defects and diseases, including cancer ...
Tijana Šopin +4 more
doaj +1 more source
Aquaculture Reports, 2020 Trichlorfon (TCF) is an antiparasitic agent used in aquaculture to treat external parasites and it belongs to the chemical class of organophosphates. This study was conducted to investigate the ameliorating effects of lycopene on TCF-induced toxicity in ...
Serpil Mişe Yonar +4 more
doaj +1 more source
Inhibition of Tcf-4 induces apoptosis and enhances chemosensitivity of colon cancer cells. [PDF]
PLoS ONE, 2012 Aberrant activation of β-catenin/Tcf-4 signaling has been implicated in human carcinogenesis, including colorectal cancer. In this study, we compared the effects of Tcf-4 knockdown with β-catenin knockdown on cell proliferation, apoptosis, and ...
Jiang Xie +7 more
doaj +1 more source
Limit of quantitation results, TCF.
, 2020 Limit of quantitation results, TCF.
Aoy Tomita-Mitchell (240230) +14 more
core +1 more source
Konservierte und nicht-konservierte Funktionen der Lef/Tcf Transkriptionsfaktoren [PDF]
, 2012 Die Lef/Tcf Transkriptionsfaktoren sind die nukleären Mediatoren des Wnt-Signalwegs. In allen bisher untersuchten Invertebraten liegt je nur ein Ortholog vor.
Klingel, Susanne
core +1 more source
Angewandte Chemie, EarlyView.Catalytic strain‐release ring opening and functionalizations of 1‐azabicyclo[1.1.0]butanes (ABBs) represent a promising strategy for accessing diverse azetidine products. These transformations proceed via polar pathways, radical pathways, and hybrid mechanisms that combine both.
James Shao‐Jiun Yang +1 more
wiley +2 more sources
Long-Lasting WNT-TCF Response Blocking and Epigenetic Modifying Activities of Withanolide F in Human Cancer Cells. [PDF]
PLoS ONE, 2016 The WNT-TCF signaling pathway participates in adult tissue homeostasis and repair, and is hyperactive in a number of human diseases including cancers of the colon. Whereas to date there are no antagonists approved for patient use, a potential problem for
Chandan Seth +7 more
doaj +1 more source
Cell Reports, 2021 Summary: Mouse embryonic stem cells (mESCs) can be maintained in vitro in defined N2B27 medium supplemented with two chemical inhibitors for GSK3 and MEK (2i) and the cytokine leukemia inhibitory factor (LIF), which act synergistically to promote self ...
Nikolaos Doumpas +6 more
doaj +1 more source
PLoS ONE, 2016 Human colon cancers commonly harbor loss of function mutations in APC, a repressor of the canonical WNT pathway, thus leading to hyperactive WNT-TCF signaling. Re-establishment of Apc function in mice, engineered to conditionally repress Apc through RNAi,
Chandan Seth, Ariel Ruiz i Altaba
doaj +1 more source