Results 51 to 60 of about 46,097 (206)

Engineering Spatially Localized Bioactive Microenvironments in Assembly Implants for Spatially Extended Bone Ingrowth

Advanced Science, EarlyView.
An assembly porous titanium/β‐TCP implant is developed to establish a spatially programmable osteogenic microenvironment for enhanced osseointegration. By decoupling mechanical support from bioactive ion release, localized ionic gradients generated from the β‐TCP module direct osteogenic activity and bone ingrowth toward the porous titanium framework ...
Heng Zhang, Jingjing Diao, Junhua Ke, Naru Zhao, Yudi Kuang, Yingjun Wang   +5 more
wiley   +1 more source

Functional localization and competition between the androgen receptor and T-cell factor for nuclear -catenin : a means for inhibition of the Tcf signaling axis

, 2003
Recent reports suggest that the -catenin-T-cell factor (Tcf) (BCT) signaling pathway is important in the progression of prostate cancer. Evidence suggests that the androgen receptor (AR) can repress BCT-mediated transcription both in prostate cancer and ...
Mulholland, David, Rennie, Paul S., Read, Jason T., Nelson, Colleen C., Cox, Michael E.   +4 more
core   +1 more source

Colossal Modulation of Mechanical Resonance with temperature in single‐Crystalline SrTiO3 Microbridges Integrated on Silicon

Advanced Electronic Materials, EarlyView.
The structural characteristics and resonant mechanical behavior of suspended microbridges comprised of single‐crystalline SrTiO3 that has been grown on silicon are presented. Due to differences in thermal expansion between the SrTiO3 and silicon, we find that the resonant frequencies of the microbridges are not only enhanced, but also hyper‐sensitive ...
Deepa Guragain, Laveeza Ahmad, Alexander A. Puretzky, Carson Hester, Zheng Hui Lim, Richard Le, Sundeep Mukherjee, Ye Cao, Joseph H. Ngai   +8 more
wiley   +1 more source

Loss of the SxxSS motif in a human T-cell factor-4 isoform confers hypoxia resistance to liver cancer: an oncogenic switch in Wnt signaling. [PDF]

PLoS ONE, 2012
Aberrantly activated Wnt/β-catenin signaling is important in hepatocellular carcinoma (HCC) development. Downstream gene expressions involving the Wnt/β-catenin cascade occur through T-cell factor (TCF) proteins.
Hironori Koga, Orkhontuya Tsedensodnom, Yoshito Tomimaru, Evan J Walker, Han Chu Lee, Kang Mo Kim, Hirohisa Yano, Jack R Wands, Miran Kim   +8 more
doaj   +1 more source

Ultra-Sensitive Intensity Modulated Strain Sensor by Tapered Thin-Core Fiber Based Modal Interferometer

Photonics, 2021
In this paper, to enhance practicality, a novel tapered thin-core fiber (t-TCF) based modal interferometer is proposed and demonstrated experimentally. The light field distribution of t-TCF structure is investigated by a beam propagation method, and the ...
Chuanxu Liu, Dexue Sun, Jiuru Yang, Hui Zhang, Lingling Ran   +4 more
doaj   +1 more source

Highly stretchable and transparent conductive film made of Pt nanocoil web

Mechanical Engineering Journal, 2017
High electrical conductivity and high optical transparency are desired for transparent conductive films (TCFs). The currently used conducting material, indium tin oxide (ITO), is high cost owing to the lack of indium source.
Xu ZHAO, Yuki SHITAMURA, Mikio MURAOKA
doaj   +1 more source

miR-26b-5p/TCF-4 Controls the Adipogenic Differentiation of Human Adipose-derived Mesenchymal Stem Cells

Cell Transplantation, 2020
In this study, we assessed the ability of miR-26b-5p to regulate T cell factor 4 (TCF-4) expression and thereby control human adipose-derived mesenchymal stem cell (hADMSC) adipogenic differentiation.
Yadong Luo, Huan Ji, Yan Cao, Xu Ding, Meng Li, Haiyang Song, Sheng Li, Chenxing WaTableng, Heming Wu MD, Jian Meng, Hongming Du   +10 more
doaj   +1 more source

Protein expression of TCF-4 isoforms J and K.

, 2012
(A) Organization of the “short” (A, B) and the “long” (J, K) isoforms; TCF-4B and J lack the SxxSS motif. (B) Confocal laser-scanning microscopy demonstrates nuclear localization of TCF-4J and TCF-4K (green). Nuclei are counterstained by DAPI.
Hironori Koga (23332), Han Chu Lee (154230), Miran Kim (154252), Evan J. Walker (154226), Jack R. Wands (154248), Orkhontuya Tsedensodnom (154217), Kang Mo Kim (154235), Yoshito Tomimaru (154221), Hirohisa Yano (154242)   +8 more
core   +1 more source

Distinct DNA binding sites contribute to the TCF transcriptional switch in C. elegans and Drosophila. [PDF]

PLoS Genetics, 2014
Regulation of gene expression by signaling pathways often occurs through a transcriptional switch, where the transcription factor responsible for signal-dependent gene activation represses the same targets in the absence of signaling.
Chandan Bhambhani, Aditi J Ravindranath, Remco A Mentink, Mikyung V Chang, Marco C Betist, Yaxuan X Yang, Sandhya P Koushika, Hendrik C Korswagen, Ken M Cadigan   +8 more
doaj   +1 more source

Fluid‐induced slip on a rate‐and‐state fault during co‐ and post‐injection: The interplay of fluid pressure diffusion and poroelastic stress

Deep Underground Science and Engineering, EarlyView.
Fault slip can occur ahead of the injection pressure front due to poroelastic stress. Our model captures the interaction of pressure, stress, and friction, providing new insights into injection‐induced seismicity and post‐injection fault slip. Shut‐in operations can either mitigate or accelerate seismic events depending on fault conditions and ...
Qifeng Xie, Lei Wang, Qi Li
wiley   +1 more source