Results 151 to 160 of about 26,882 (189)

Targeting Wnt/β-Catenin Pathway by DNA Alkylating Pyrrole-Imidazole Polyamide in Colon Cancer. [PDF]

Cancer Sci
Shimozato O, Akao N, Yanagisawa Y, Mori Y, Zhang X, Kida Y, Igarashi R, Watanabe T, Ozaki T, Takatori A.   +9 more
europepmc   +1 more source

The inwardly rectifying potassium channel KCNJ12 regulates the stemness of hepatocellular carcinoma cells through the Wnt/β-catenin pathway. [PDF]

J Mol Cell Biol
Zhao Z, Bai M, Wang S, Zhang Y, Liu S, Bao M, Lu S, Cao D, Shen S, Xie L, Wang H, Chen L.   +11 more
europepmc   +1 more source

T Cell Exhaustion in Cancer Immunotherapy: Heterogeneity, Mechanisms, and Therapeutic Opportunities. [PDF]

Adv Sci (Weinh)
Yu Y, Yao X, Wang Q, Yang M, Li R, Qin J, Zhuang J, Sun C.   +7 more
europepmc   +1 more source

Tcf transcription factors instruct lineage (subtype) specification in human breast cancer.

openaire   +2 more sources

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TCF transcription factors: molecular switches in carcinogenesis

Biochimica Et Biophysica Acta: Reviews on Cancer, 1999
Although originally cloned as lymphoid transcription factors, members of the T-cell factor (Tcf) family are now well recognized as key activators/repressors in many developmental processes. Transcriptionally inert Tcf factors become potent transactivators upon interaction with the Wnt signaling product beta-catenin or its Drosophila counterpart ...
Hans Clevers
exaly   +5 more sources

Drosophila CBP represses the transcription factor TCF to antagonize Wingless signalling

Nature, 1998
T-cell factor (TCF), a high-mobility-group domain protein, is the transcription factor activated by Wnt/Wingless signalling. When signalling occurs, TCF binds to its coactivator, beta-catenin/Armadillo, and stimulates the transcription of the target genes of Wnt/Wingless by binding to TCF-responsive enhancers.
Mariann Bienz, Bienz Mariann
exaly   +3 more sources

Lineage-Determining Transcription Factor TCF-1 Initiates the Epigenetic Identity of T Cells [PDF]

Immunity, 2018
T cell development is orchestrated by transcription factors that regulate the expression of genes initially buried within inaccessible chromatin, but the transcription factors that establish the regulatory landscape of the T cell lineage remain unknown.
Golnaz Vahedi, Warren Pear, Avinash Bhandoola   +2 more
exaly   +4 more sources

Wnt target enhancer regulation by a CDX/TCF transcription factor collective and a novel DNA motif [PDF]

Nucleic Acids Research, 2021
Abstract Transcriptional regulation by Wnt signalling is primarily thought to be accomplished by a complex of β-catenin and TCF family transcription factors (TFs). Although numerous studies have suggested that additional TFs play roles in regulating Wnt target genes, their mechanisms of action have not been ...
Peter Burby, Aravindabharathi Ramakrishnan, Ken Cadigan   +2 more
exaly   +4 more sources