Results 161 to 170 of about 26,882 (189)
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Regulation of LEF-1/TCF transcription factors by Wnt and other signals
Current Opinion in Cell Biology, 1999LEF-1/TCF transcription factors mediate a nuclear response to Wnt signals by interacting with beta-catenin. Wnt signaling and other cellular events that increase the stability of beta-catenin result in transcriptional activation by LEF-1/TCF proteins in association with beta-catenin.
Q, Eastman, R, Grosschedl
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The Transcription Factor TCF/Elk-1
1996The ternary complex factor (TCF) and the serum response factor (SRF) are nuclear transcription factors which are essential for efficient signal transduction via the serum response element SRE in the c-fos promoter. Their activation leads to a rapid induction of c-fos gene expression.
Judith M. Müller +3 more
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TCF/LEF family transcription factors in peripheral Treg homeostasis
The Journal of Immunology, 2018Abstract CD4+Foxp3+ regulatory T cells (Tregs) are key players in preventing lethal autoimmunity and excessive inflammation. However, the homeostatic dynamics of Tregs in peripheral lymphoid and non-lymphoid tissues remains poorly defined. We here report that two TCF/LEF family transcription factors, LEF1 and TCF1, play critical roles in
Wenxian Fu +3 more
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European Journal of Immunology, 1992
AbstractSeveral mammalian T cell‐specific transcription factors have been cloned recently. Two of these, TCF‐1 and TCF‐1α/LEF‐1, display a moderate level of overall sequence similarity, and contain virtually identical versions of a novel type of DNA‐binding domain, the HMG box.
J, Gastrop +3 more
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AbstractSeveral mammalian T cell‐specific transcription factors have been cloned recently. Two of these, TCF‐1 and TCF‐1α/LEF‐1, display a moderate level of overall sequence similarity, and contain virtually identical versions of a novel type of DNA‐binding domain, the HMG box.
J, Gastrop +3 more
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Nature Immunology, 2023
In development, pioneer transcription factors access silent chromatin to reveal lineage-specific gene programs. The structured DNA-binding domains of pioneer factors have been well characterized, but whether and how intrinsically disordered regions affect chromatin and control cell fate is unclear.
Naomi Goldman +16 more
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In development, pioneer transcription factors access silent chromatin to reveal lineage-specific gene programs. The structured DNA-binding domains of pioneer factors have been well characterized, but whether and how intrinsically disordered regions affect chromatin and control cell fate is unclear.
Naomi Goldman +16 more
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Tcf/Lef transcription factors during T-cell development: unique and overlapping functions
The Hematology Journal, 2000The founding members of the TCF family are T-cell factor-1 (Tcf-1) and lymphoid enhancing factor-1 (Lef-1). In adult mammals, Tcf-1 is uniquely expressed in T lymphocytes, while Lef-1 is expressed in T cells and early B cells. During murine development, however, expression of Tcf-1 and Lef-1 occurs in complex overlapping patterns in many tissues.
F J, Staal, H, Clevers
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Annals of the New York Academy of Sciences, 2009
Rxfp2 is present in putative mesangial cells at embryonic stage 18 (E18) in the rat kidney, suggesting that insulin‐like peptide 3 is involved in glomerulogenesis. One of the main regulatory factors in glomerulogenesis is the basic helix‐loop‐helix transcription factor Pod1.
Mary, Familari, Duc, Vu, Laura J, Parry
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Rxfp2 is present in putative mesangial cells at embryonic stage 18 (E18) in the rat kidney, suggesting that insulin‐like peptide 3 is involved in glomerulogenesis. One of the main regulatory factors in glomerulogenesis is the basic helix‐loop‐helix transcription factor Pod1.
Mary, Familari, Duc, Vu, Laura J, Parry
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3rd International Conference on Osteopontin and SIBLING (Small Integrin-Binding Ligand, N-linked Glycoprotein) Proteins, 2002, 2002
Small 1,000-bp fragments of genomic DNA obtained from human malignant breast cancer cell lines when transfected into a benign rat mammary cell line enhance transcription of the osteopontin gene and thereby cause the cells to metastasize in syngeneic rats.
El-Tanani, Mohamed +3 more
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Small 1,000-bp fragments of genomic DNA obtained from human malignant breast cancer cell lines when transfected into a benign rat mammary cell line enhance transcription of the osteopontin gene and thereby cause the cells to metastasize in syngeneic rats.
El-Tanani, Mohamed +3 more
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International Journal of Oncology, 2004
Tcf family transcription factors are the downstream effectors of the Wnt signal transduction pathway that regulates developmental and oncogenetic processes among species. The alternative splicing of consecutive exons in the 3' part of the Tcf-4 gene and an error-prone A9 repeat in exon 17 have recently been examined in several tumors.
Shen-Long, Howng +6 more
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Tcf family transcription factors are the downstream effectors of the Wnt signal transduction pathway that regulates developmental and oncogenetic processes among species. The alternative splicing of consecutive exons in the 3' part of the Tcf-4 gene and an error-prone A9 repeat in exon 17 have recently been examined in several tumors.
Shen-Long, Howng +6 more
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Archives of Medical Research, 2001
TCF, TPF/YY1, and the Sp family are specific transcription factors that bind sequences found within the uteroglobin (UG) gene promoter region that are necessary for transcription. To date, UG gene expression and regulation in vivo are not fully understood.
J, Arias +3 more
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TCF, TPF/YY1, and the Sp family are specific transcription factors that bind sequences found within the uteroglobin (UG) gene promoter region that are necessary for transcription. To date, UG gene expression and regulation in vivo are not fully understood.
J, Arias +3 more
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