Results 291 to 300 of about 272,710 (333)

TCR repertoires of intratumoral T‐cell subsets

Immunological Reviews, 2013
SummaryThe infiltration of human tumors by T cells is a common phenomenon, and over the past decades, it has become increasingly clear that the nature of such intratumoral T‐cell populations can predict disease course. Furthermore, intratumoral T cells have been utilized therapeutically in clinical studies of adoptive T‐cell therapy. In this review, we
Carsten, Linnemann, Riccardo, Mezzadra, Ton N M, Schumacher   +2 more
openaire   +2 more sources

TCR repertoire analysis reveals phosphoantigen‐induced polyclonal proliferation of Vγ9Vδ2 T cells in neonates and adults

Journal of Leukocyte Biology, 2020
The Vγ9Vδ2 T cell subset is the major γδ T cell subset in human peripheral blood and has the unique ability to contribute to immune surveillance by detecting pyrophosphorylated metabolites of isoprenoid synthesis, termed phosphoantigens (pAgs).
A. S. Fichtner, Anja Bubke, Francesca Rampoldi, A. Wilharm, Likai Tan, L. Steinbrück, Christian R. Schultze-Florey, C. von Kaisenberg, I. Prinz, T. Herrmann, S. Ravens   +10 more
semanticscholar   +1 more source

Individuality of Ag-Selected and Preimmune TCR Repertoires

Immunologic Research, 2001
We have combined flow cytometry and single-cell PCR to characterize the TCRBV repertoires selected by individual mice in a model CD8 response against a defined peptide/MHC complex (CW3 170-1 79/Kd). Ourresults established thatdifferent mice select individually distinct yet structurally similar CW3-specific repertoires.
J L, Maryanski, V, Attuil, A, Hamrouni, M, Mutin, M, Rossi, A, Aublin, P, Bucher   +6 more
openaire   +2 more sources

Characterizing the TCR repertoire in Neuropsychiatric Lupus

The Journal of Immunology, 2020
Abstract Approximately 40% of lupus patients experience neurological and/or psychiatric disorders. However, the mechanisms contributing to the wide range of neuropsychiatric manifestations (NPSLE) have not yet been fully elucidated.
Erica Moore, Michelle Huang, Chaim Putterman   +2 more
openaire   +1 more source

T cell diversity and TcR repertoires in teleost fish

Fish & Shellfish Immunology, 2011
In vertebrates, the diverse and extended range of antigenic motifs is matched to large populations of lymphocytes. The concept of immune repertoire was proposed to describe this diversity of lymphocyte receptors--IG and TR--required for the recognition specificity.
Castro Sequeiro, Dona Maria Rosario, Bernard, David, Lefranc, M.P., Six, A., Benmansour, Abdenour, Boudinot, Pierre   +5 more
openaire   +4 more sources

Comprehensive TCR repertoire analysis of CD4+ T-cell subsets in rheumatoid arthritis.

Journal of Autoimmunity, 2020
The pathogenesis of rheumatoid arthritis (RA), a systemic autoimmune disease characterized by autoreactive T-cell accumulation and pro-inflammatory cytokine overproduction, is unclear.
Xu Jiang, Shiyu Wang, Chen Zhou, Jinghua Wu, Yu-hao Jiao, Liya Lin, Xin Lu, Bo Yang, Wei Zhang, Xin-yue Xiao, Yueting Li, Xunyao Wu, Xie Wang, Hua Chen, Lidan Zhao, Y. Fei, Huaxia Yang, W. Zhang, Fengchun Zhang, Hui Chen, Jianmin Zhang, Bin Li, H. Yang, Jian Wang, Xiao Liu, Xuan Zhang   +25 more
semanticscholar   +1 more source

Spectratype/Immunoscope Analysis of the Expressed TCR Repertoire

Current Protocols in Immunology, 2000
AbstractMeasuring the diversity of TCRs utilized by specific primary and memory T cell responses is critical to the fundamental understanding of regulation of the immune system. This unit describes the Spectratype/Immunoscope technique which permits an in depth analysis of the TCR repertoire present in a variety of biological samples from mice to ...
Jeffrey R, Currier, Mary Ann, Robinson
openaire   +2 more sources

The TCR-? chain repertoire of gut-derived T lymphocytes

Seminars in Immunology, 1995
The gastrointestinal tract represents a natural barrier to environmental pathogens. The gut-associated lymphoid tissue (GALT) provides protection and interacts with the external environment, e.g. bacteria and food antigens. Large numbers of leukocytes are present as aggregates in the lymphoid follicles and as single cells in the lamina propria and ...
A, Regnault, P, Kourilsky, A, Cumano
openaire   +2 more sources

TCR-beta repertoire development in the mouse embryo.

The Journal of Immunology, 1997
Abstract We studied the TCR beta-chain repertoire in thymocytes along embryonic development. At day 14 of gestation, complete V-D-J rearrangements of the TCR-beta locus were detected at the messenger RNA level, and a total of 56 different rearrangements were observed in one thymus.
H, Ema, A, Cumano, P, Kourilsky
openaire   +2 more sources

Characterization of peripheral blood TCR repertoire in patients with ankylosing spondylitis by high-throughput sequencing.

Human Immunology, 2018
Ankylosing spondylitis (AS) is a chronic and progressive autoimmune disease affecting the invasion of the spine, sacroiliac joints and peripheral joints.
J. Cui, Yabin Jin, Kai-rong Lin, Ping Xiao, Xiang-ping Chen, Ying-ming Pan, Wei Lin, Zuchang Wu, Dong-mei Guo, Xiao-fan Mao, Chu-ling Zhang, Wen-Lue Lian, W. Luo   +12 more
semanticscholar   +1 more source