Results 151 to 160 of about 22,324 (258)

Combined Vitamin D and Resveratrol Treatment Attenuates Motor Deficits and Neurodegeneration in a 6‐OHDA Mouse Model of Parkinson's Disease in Male Mice: A Focus on Sirt1 and Lingo‐1 Pathways in the Ventral Tegmental Area

open access: yesBrain and Behavior, Volume 16, Issue 8, August 2026.
Combined treatment with VitD3 and resveratrol mitigates motor deficits and neurodegeneration in 6‐OHDA‐lesioned mice which was associated with activation of Sirt1 and suppression of Lingo‐1. ABSTRACT Background Parkinson's disease (PD) is characterized by progressive dopaminergic neurodegeneration, leading to severe motor impairments.
Monavareh Soti   +5 more
wiley   +1 more source

Alpha‐Mannosidosis in a 3.5‐Year‐Old Girl: A Case Report

open access: yesClinical Case Reports, Volume 14, Issue 8, August 2026.
ABSTRACT Alpha‐mannosidosis is a rare lysosomal storage disease caused by a deficiency of the enzyme alpha‐mannosidase. It manifests as a continuous spectrum of signs and symptoms characterized by dysmorphic features, skeletal abnormalities, delayed psychomotor and speech development, impaired hearing, and psychiatric involvement. When suspected, alpha‐
Samuel Bonilla Fornes   +4 more
wiley   +1 more source

A Review of Virtual Twins in Physiologically‐Based Pharmacokinetic Modeling and Simulation

open access: yesClinical Pharmacology &Therapeutics, Volume 120, Issue 2, Page 324-333, August 2026.
The novel application of Virtual Twins (VT) in PBPK (VT‐PBPK) presents the opportunity to advance precision dosing and accelerate the shift from one‐size‐fits‐all to targeted, individualized treatments. This review aims to: (1) critically evaluate existing research on the use of VTs in PBPK, (2) develop a conceptual definition of VT‐PBPK, (3) describe ...
Emily Mannix   +4 more
wiley   +1 more source

Study on Analysis of Dispersion for TDM‐GPON System With Different Parameters

open access: yesEngineering Reports, Volume 8, Issue 8, August 2026.
The workflow and simulated outcomes of a 32‐user bidirectional TDM‐GPON system simulated in OptiSystem 19 to evaluate the effects of optical fiber dispersion under various data rates, fiber lengths, and dispersion levels are shown in the graphical abstract.
Molla Belete Salelgne   +2 more
wiley   +1 more source

The Impact of the Common Elements Treatment Approach on HIV Treatment Outcomes Among Women Experiencing Intimate Partner Violence in South Africa: A Randomized Trial

open access: yesJournal of the International AIDS Society, Volume 29, Issue 8, August 2026.
ABSTRACT Introduction In South Africa, which has the world's highest prevalence of HIV, intimate partner violence (IPV) and common mental health conditions are barriers to retention in HIV treatment and achieving viral suppression. The Common Elements Treatment Approach (CETA), a cognitive‐behavioural‐therapy‐based intervention designed for lay ...
Matthew P. Fox   +14 more
wiley   +1 more source

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