Analytical Science Advances, Volume 7, Issue 2, December 2026.Quantitative isotope‐dilution liquid chromatography coupled with tandem mass spectrometry analyses generate extensive metadata that require time‐consuming manual validation in laboratory workflows. We developed MSVal, an Excel‐based tool that applies predefined quality criteria to automatically evaluate results and highlight deviations.
Verena Endt +2 more
wiley +1 more source
Induction-phase infliximab monitoring accelerates time to remission in pediatric IBD: a retrospective cohort study. [PDF]
Crohns Colitis 360Iovino N +6 more
europepmc +1 more source
American Journal of Hematology, Volume 101, Issue 11, Page 2713-2725, November 2026.ABSTRACT Asparaginase is a critical treatment component for patients with acute lymphoblastic leukemia/lymphoblastic lymphoma (ALL/LBL). However, the successful delivery of asparaginase‐based therapy remains challenging across care settings due to its complex administration, distinct toxicity profile, prolonged treatment duration, and the need for ...
Amir Ali +8 more
wiley +1 more source
Dose Exploration Based on Quantitative Pharmacokinetic Analysis of Monoclonal Antibodies for Pediatric Immune-Mediated Diseases: Current Evidence and Future Directions. [PDF]
Drug Des Devel TherLi S, Ma M, Wang N, Zheng X, Han X.
europepmc +1 more source
Hematological Oncology, Volume 44, Issue 6, November 2026.ABSTRACT In recent years the addition of the oral BCL2 inhibitor venetoclax to hypomethylating agents (HMAs) has emerged as the standard‐of‐care for patients with acute myeloid leukemia (AML) who are not fit for intensive chemotherapy, significantly improving survival and quality‐of‐life.
Mariarita Sciumè +9 more
wiley +1 more source
A Retrospective Cohort Study to Optimize Piperacillin/Tazobactam Dosing in Routine Intensive-Care Patients via a Newly Designed Clinical Pharmacy Service Including TDM- and Algorithm-Based Recommendations. [PDF]
Pharmacy (Basel)Dicken J +4 more
europepmc +1 more source
JCC Plus, Volume 1, Issue 6, November 2026.In this meta‐analysis of eight studies (508 children with inflammatory bowel disease), switching from originator to biosimilar infliximab preserved clinical remission, drug exposure, and immunogenicity, with high treatment persistence and no signal of efficacy or safety loss. Biosimilar switching appears a safe, effective option in pediatric IBD.
Douglas Amaral da Silva Menegazzo Miotto +4 more
wiley +1 more source
Therapeutic Drug Monitoring and Adverse Drug Reactions: From Signal Detection to Prevention. [PDF]
Pharmaceuticals (Basel)Algharably E, Gundert-Remy U.
europepmc +1 more source
JCC Plus, Volume 1, Issue 6, November 2026.This national, multisite, nurse‐led evaluation highlights practice patterns across UK IBD centres, revealing reliance on reactive flare‐driven treatment modification. Balancing this with structured proactive surveillance and therapeutic drug monitoring aligns with treat‐to‐target principles and supports safer advanced therapy care across diverse ...
Vida Cairnes +18 more
wiley +1 more source
Pharmaco-multiomics in major depressive disorder: a narrative review and proposed translational framework for difficult-to-treat and treatment-resistant depression. [PDF]
Front PharmacolBaune BT.
europepmc +1 more source