British Journal of Clinical Pharmacology, Volume 92, Issue 10, Page 3460-3465, October 2026.Abstract Aim Paroxysmal nocturnal haemoglobinuria (PNH) is a rare, acquired haematopoietic stem cell disorder. Crovalimab, a complement C5‐inhibitor, is approved for PNH and can be self‐administered subcutaneously every 4 weeks, offering a more convenient route than intravenous C5‐inhibitors.
Mendy ter Avest +4 more
wiley +1 more source
Bayesian-Estimated Vancomycin AUC24 as a Near-Term Renal Risk Signal after Therapeutic Drug Monitoring: A Multicenter Cohort Study. [PDF]
J Clin PharmacolVan Anh T +8 more
europepmc +1 more source
British Journal of Clinical Pharmacology, Volume 92, Issue 10, Page 3646-3655, October 2026.Aim Meropenem is a second‐line antimicrobial agent in the treatment of febrile neutropenia in onco‐haematological patients. A population pharmacokinetic/pharmacodynamic (PK/PD) analysis for assessing the relationship between meropenem exposure and C‐reactive protein (C‐RP) over time was conducted.
Chun Liu +7 more
wiley +1 more source
Development and validation of a pharmacokinetic tool to convert random topiramate concentrations to standardized trough levels in bipolar disorder. [PDF]
Front PharmacolJv X +7 more
europepmc +1 more source
British Journal of Clinical Pharmacology, Volume 92, Issue 10, Page 3598-3610, October 2026.Prior glucocorticoid exposure is associated with modestly increased vancomycin clearance in hospitalized children, partly mediated by renal function and inflammation and may contribute to subtherapeutic early drug exposure. Abstract Introduction Augmented renal clearance (ARC) can lead to subtherapeutic vancomycin exposure in children.
Kouki Tomari +6 more
wiley +1 more source
Therapeutic drug monitoring-guided management of venlafaxine overdose in an adolescent: a case report. [PDF]
J Anal ToxicolKrivošová M +6 more
europepmc +1 more source
Breath Signatures of Antiseizure Medication Response and Tolerability in Adults With Epilepsy
CNS Neuroscience &Therapeutics, Volume 32, Issue 10, October 2026.Breath metabolomic profiles distinguish treatment response and adverse effects in adults with epilepsy, whereas serum antiseizure medication concentrations do not. These findings support breath analysis as a non‐invasive approach to pharmacodynamic phenotyping, capturing treatment‐related metabolic states relevant to complex human disease.
Kai Fricke +11 more
wiley +1 more source
An Ultra‐Low‐Power Biopotential Acquisition Analog Front‐End Chip for Wearable Devices
International Journal of Circuit Theory and Applications, Volume 54, Issue 10, Page 5030-5044, October 2026.A 0.8‐V, 1.2‐μW biopotential AFE combines a chopper‐stabilized CCIA with dual‐time‐scale EDO management. The slow DSL preserves > 1 GΩ input impedance, whereas an event‐triggered fast‐recovery path shortens return to the linear range after abrupt electrode‐offset disturbances. ABSTRACT A 0.8‐V, 1.2‐μW biopotential analog front‐end (AFE) IC is presented
Zhang Xin +4 more
wiley +1 more source
Reevaluating the rule of two's: Age and epidemiological variations in Meckel's diverticulum
Journal of Pediatric Gastroenterology and Nutrition, Volume 83, Issue 4, Page 658-664, October 2026.Abstract Objective To evaluate the clinical characteristics, diagnostic modalities, and age‐related variation of Meckel's diverticulum (MD) using data from a nationwide pediatric inpatient database and a single‐center institutional cohort. Methods The Kids' Inpatient Database (KID) for 2016 and 2019 was queried for patients with a principal diagnosis ...
Ashley Polachek +5 more
wiley +1 more source
Therapeutic drug-monitoring-guided desensitization for severe imatinib-associated rash. [PDF]
J Gastrointest OncolDy PS, Lou E.
europepmc +1 more source