Results 51 to 60 of about 22,324 (258)

Relationship between continuous infusion meropenem PK/PD target attainment and C‐reactive protein dynamics in onco‐haematologic patients with febrile neutropenia

British Journal of Clinical Pharmacology, EarlyView.
Aim Meropenem is a second‐line antimicrobial agent in the treatment of febrile neutropenia in onco‐haematological patients. A population pharmacokinetic/pharmacodynamic (PK/PD) analysis for assessing the relationship between meropenem exposure and C‐reactive protein (C‐RP) over time was conducted.
Chun Liu, Pier Giorgio Cojutti, J. G. Coen van Hasselt, Michele Bartoletti, Maddalena Giannella, Pierluigi Zinzani, Pierluigi Viale, Federico Pea   +7 more
wiley   +1 more source

Impact of cumulative glucocorticoid exposure on vancomycin clearance in hospitalized children: A retrospective cohort study

British Journal of Clinical Pharmacology, EarlyView.
Prior glucocorticoid exposure is associated with modestly increased vancomycin clearance in hospitalized children, partly mediated by renal function and inflammation and may contribute to subtherapeutic early drug exposure. Abstract Introduction Augmented renal clearance (ARC) can lead to subtherapeutic vancomycin exposure in children.
Kouki Tomari, Ruud H. J. Verstegen, Cintia Cruz, Erin Chung, Aleena Azim, Shinya Ito, Tamorah R. Lewis   +6 more
wiley   +1 more source

Monitoring pharmacodynamic and molecular drug targets in liquid biopsy: Exploratory study in liver cancer with modelling of EGFR Receptor engagement

British Journal of Clinical Pharmacology, EarlyView.
Abstract Aim Liquid biopsy is minimally invasive (compared with tissue biopsy) and has previously been used to generate systems data regarding drug elimination via hepatic enzymes and transporters. This study extends quantitative assessment of systems parameters in liquid biopsy to pharmacodynamic (PD) and disease markers relevant to cancer development
Zubida M. Al‐Majdoub, Armin Sepp, Amin Rostami‐Hodjegan, Brahim Achour   +3 more
wiley   +1 more source

Kystes hydatiques cérébraux de l'enfant: à propos de 15 cas

The Pan African Medical Journal, 2017
L'objectif de notre étude est d'illustrer l'intérêt de l''imagerie en coupe (TDM, IRM) dans le diagnostic positif et le suivi post-thérapeutique du kyste hydatique cérébral chez l'enfant et de mettre en lumière les particularités et les difficultés ...
Abderrazzak El Saqui, Mohamed Aggouri, Mohamed Benzagmout, Khalid Chakour, Mohamed El Faiz Chaoui   +4 more
doaj   +1 more source

Anosmie : alerte COVID-19

PAMJ Clinical Medicine, 2020
L´anosmie est un symptôme fréquent en cas d´infection au SARS-CoV-2 responsable du COVID-19. Elle peut être le symptôme initial de la maladie ou rester isolée chez certains patients pauci symptomatiques.
Rachidi Alaoui Siham, Rkain Ilham
doaj   +1 more source

Fungal Antimicrobial Resistance: Mechanisms, Drivers, and Global Clinical Burden

ChemFoodChem, EarlyView.
ABSTRACT Fungal antimicrobial resistance (AMR) is a growing concern for world health caused by an increase in multidrug‐resistant infections, an increase in environmental reservoirs, and the ineffectiveness of current antifungal treatments. Fungal infections continue to be largely excluded from AMR initiatives while causing over 1.6 million deaths ...
Bikash Baral
wiley   +1 more source

Involuntary intoxication caused by vaping the synthetic cannabinoid ADB-BUTINACA: A case report

Toxicology Reports
Synthetic cannabinoids are gaining popularity globally and detection is not commonly available. We report a 27-year-old man who was admitted to the emergency room because of sudden headache, nausea, vertigo, red eyes and palpitations.
Elise M.A. Slob, Maryam Lyousoufi, Sharif Pasha, Erik B. Wilms   +3 more
doaj   +1 more source

The Pharmacokinetics/Pharmacodynamics and Neurotoxicity of Tigecycline Intraventricular Injection for the Treatment of Extensively Drug-Resistant Acinetobacter baumannii Intracranial Infection

Infection and Drug Resistance, 2022
Qi Huang,1 Xingwen Zhang,2 Aijun Jia,2 Qi Huang,3 Yu Jiang,4 Liangyi Xie5 1Department of Pharmacy, Hunan Provincial People’s Hospital (The first-affiliated hospital of Hunan normal university), Changsha, People’s Republic of China; 2Emergency Intensive ...
Huang Q, Zhang X, Jia A, Huang Q, Jiang Y, Xie L   +5 more
doaj  

A Concept of a Hybrid WDM/TDM Topology Using the Fabry-Perot Laser in the Optiwave Simulation Environment

Advances in Electrical and Electronic Engineering, 2011
The aim of this article is to point out the possibility of solving problems related to a concept of a flexible hybrid optical access network. The entire topology design was realized using the OPTIWAVE development environment in which particular test ...
Radek Poboril, Jan Latal, Petr Koudelka, Jan Vitasek, Petr Siska, Jan Skapa, Vladimir Vasinek   +6 more
doaj   +1 more source

Clinical Model‐Informed Precision Dosing Consult Service for Accelerating Personalized Medication in Pediatric Patients

Clinical Pharmacology &Therapeutics, EarlyView.
Traditional dosing strategies often rely on a “one‐size‐fits‐all” paradigm, assuming an “average” patient with typical demographic and pharmacological characteristics. In reality, this often overlooks existing between‐patient variability and can lead to suboptimal drug exposure or toxicity. This issue is especially pronounced in pediatric patients, who
Zachary L. Taylor, Takanobu Nadai, Kei Irie, Wen Rui Tan, Sanjana Parikh, Anhar Hosawi, Matthijs W. van Hoogdalem, Ronaldo Morales Junior, Sonya Tang Girdwood, Abbie D. Leino, Kana Mizuno, Alexander A. Vinks, Tomoyuki Mizuno   +12 more
wiley   +1 more source