Results 71 to 80 of about 113,996 (286)

A Concept of a Hybrid WDM/TDM Topology Using the Fabry-Perot Laser in the Optiwave Simulation Environment

open access: yesAdvances in Electrical and Electronic Engineering, 2011
The aim of this article is to point out the possibility of solving problems related to a concept of a flexible hybrid optical access network. The entire topology design was realized using the OPTIWAVE development environment in which particular test ...
Radek Poboril   +6 more
doaj   +1 more source

Virtual Twin Approach Using Physiologically Based Pharmacokinetic Modeling to Support Precision Dosing of Valproic Acid in Geriatric Patients

open access: yesClinical Pharmacology &Therapeutics, EarlyView.
Personalized dosing is particularly important for drugs with narrow therapeutic indices in geriatric patients, who exhibit substantial physiological variability and limited pharmacokinetic (PK) evidence to guide individualized dose selection. Valproic acid (VPA) is an effective treatment option for bipolar disorder in older adults, yet dosing largely ...
Yoo Jin Jang   +2 more
wiley   +1 more source

Découverte tomodensitométrique d'un mésentère commun complet par perforation d'une appendicite aiguë

open access: yesThe Pan African Medical Journal, 2017
Le mésentère commun complet est une anomalie rare de rotation du tube digestif. Sa découverte est exceptionnelle à âgé adulte; à cette période, il demeure très souvent asymptomatique et donc non diagnostiquée.
Traore Abdoulaye Ababacar   +6 more
doaj   +1 more source

A TDM rendszer jellegzetességei egy hazai esettanulmány példáján keresztül

open access: yes, 2019
A hajdúszoboszlói turisztikai desztináció-menedzsment szervezet fejlődésének és működésének vizsgálata, valamint a hazai TDM rendszer működésének vizsgálata, és helyzetelemzés.gjFöldrajzBSc ...
Horváth, Péter
core  

Experimental Demonstration of a Smooth Evolution Scheme from Conventional TDM-PON to TDM-OFDM-PON

open access: yes, 2012
We proposed a smooth evolution scheme from conventional TDM-PON to TDM-OFDM-PON. We show by experiment that a TDM-OFDM-PON OLT can support upstream and downstream transmissions for conventional TDM-PON ONUs to achieve cost-effective.http://gateway ...
Yongqi He   +9 more
core   +1 more source

Non‐Invasive Estimation of Systemic Drug Exposure Using Exhaled Breath Metabolomics in Humans: A Translational Proof‐of‐Concept Study

open access: yesClinical Pharmacology &Therapeutics, EarlyView.
Accurate assessment of systemic drug exposure in humans remains challenging, as conventional approaches rely on intermittent blood sampling and laboratory‐based assays that are invasive and provide limited temporal resolution. Exhaled breath contains volatile and semi‐volatile compounds arising from drug metabolism and downstream biological processes ...
Kai Fricke   +12 more
wiley   +1 more source

Time‐Dependent Bias and Prognostic Confounding in Exposure–Response Analysis of Targeted Therapies: Lessons from Sunitinib in Metastatic Renal Cancer

open access: yesClinical Pharmacology &Therapeutics, EarlyView.
Exposure–response (E–R) analyses of sunitinib in metastatic renal cell carcinoma (mRCC) have supported concentration‐guided dose escalation. However, such analyses may be biased when exposure metrics incorporate post‐baseline dose modifications, time‐varying apparent clearance, or baseline factors that influence both pharmacokinetics and clinical ...
Han Liu, Lena E. Friberg
wiley   +1 more source

Pharmacokinetic targets of antiretroviral therapy in children and adolescents

open access: yesJournal of Pediatric and Neonatal Individualized Medicine, 2013
Large populations of HIV-infected and exposed infants, children and adolescents are increasingly exposed to antiretroviral therapy throughout dramatic changes of the body composition and maturation process in utero, perinatally and during the later ...
Michael N. Neely, Natella Y. Rakhmanina
doaj   +1 more source

Score de prédiction de récidive après un premier épisode de pneumothorax spontané primitif

open access: yesThe Pan African Medical Journal, 2020
INTRODUCTION: la relation entre les constatations scanographiques et le risque de récidive d´un pneumothorax spontané primitif (PSP) reste conflictuelle. L´objectif de cette étude est de déterminer la relation entre le score scanographique DSS (Dystrophy
Ahmed Ben Saad   +6 more
doaj   +1 more source

Traffic Management System and Travel Demand Management (TDM) Strategies: Suggestions for Urban Cities in Bangladesh

open access: yes, 2010
[[abstract]]ABSTRACT Travel demand management (TDM) has come out as a policy choice for solving transportation and traffic congestion problems by reducing and restricting travel demand instead of increasing the transportation facilities.
MONOWAR MAHMOOD   +2 more
core  

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