Results 61 to 70 of about 22,324 (258)
Clinical Pharmacology &Therapeutics, EarlyView.Personalized dosing is particularly important for drugs with narrow therapeutic indices in geriatric patients, who exhibit substantial physiological variability and limited pharmacokinetic (PK) evidence to guide individualized dose selection. Valproic acid (VPA) is an effective treatment option for bipolar disorder in older adults, yet dosing largely ...
Yoo Jin Jang +2 more
wiley +1 more source
Découverte tomodensitométrique d'un mésentère commun complet par perforation d'une appendicite aiguë
The Pan African Medical Journal, 2017 Le mésentère commun complet est une anomalie rare de rotation du tube digestif. Sa découverte est exceptionnelle à âgé adulte; à cette période, il demeure très souvent asymptomatique et donc non diagnostiquée.
Traore Abdoulaye Ababacar +6 more
doaj +1 more source
Clinical Pharmacology &Therapeutics, EarlyView.Accurate assessment of systemic drug exposure in humans remains challenging, as conventional approaches rely on intermittent blood sampling and laboratory‐based assays that are invasive and provide limited temporal resolution. Exhaled breath contains volatile and semi‐volatile compounds arising from drug metabolism and downstream biological processes ...
Kai Fricke +12 more
wiley +1 more source
Pharmacokinetic targets of antiretroviral therapy in children and adolescents
Journal of Pediatric and Neonatal Individualized Medicine, 2013 Large populations of HIV-infected and exposed infants, children and adolescents are increasingly exposed to antiretroviral therapy throughout dramatic changes of the body composition and maturation process in utero, perinatally and during the later ...
Michael N. Neely, Natella Y. Rakhmanina
doaj +1 more source
Clinical Pharmacology &Therapeutics, EarlyView.Exposure–response (E–R) analyses of sunitinib in metastatic renal cell carcinoma (mRCC) have supported concentration‐guided dose escalation. However, such analyses may be biased when exposure metrics incorporate post‐baseline dose modifications, time‐varying apparent clearance, or baseline factors that influence both pharmacokinetics and clinical ...
Han Liu, Lena E. Friberg
wiley +1 more source
Score de prédiction de récidive après un premier épisode de pneumothorax spontané primitif
The Pan African Medical Journal, 2020 INTRODUCTION: la relation entre les constatations scanographiques et le risque de récidive d´un pneumothorax spontané primitif (PSP) reste conflictuelle. L´objectif de cette étude est de déterminer la relation entre le score scanographique DSS (Dystrophy
Ahmed Ben Saad +6 more
doaj +1 more source
An Ultra‐Low‐Power Biopotential Acquisition Analog Front‐End Chip for Wearable Devices
International Journal of Circuit Theory and Applications, EarlyView.A 0.8‐V, 1.2‐μW biopotential AFE combines a chopper‐stabilized CCIA with dual‐time‐scale EDO management. The slow DSL preserves > 1 GΩ input impedance, whereas an event‐triggered fast‐recovery path shortens return to the linear range after abrupt electrode‐offset disturbances. ABSTRACT A 0.8‐V, 1.2‐μW biopotential analog front‐end (AFE) IC is presented
Zhang Xin +4 more
wiley +1 more source
Drug Design, Development and TherapyElsa Vitale,1 Alessandro Rizzo,2 Lorenza Maistrello,3 Omar Cauli,4 Oronzo Brunetti,2 Fernando Sabino Marques Monteiro,5,6 Andrey Soares,5,7 Matteo Santoni,8 Veronica Mollica,9,* Francesco Massari9,10,* 1Directorate of Health Professions ...
Vitale E +9 more
doaj
Coincidence Detection in Flow Cytometry Using Pulse‐Shape Analysis in Polydisperse Suspensions
Cytometry Part A, EarlyView.ABSTRACT Flow cytometers, based on an optical measurement principle, are widely used for cell characterization in a variety of medical applications. Especially in hematology, high counting accuracy is crucial. Therefore, it is essential to develop accurate but also fast coincidence correction methods.
Alexander Putz +2 more
wiley +1 more source