Results 121 to 130 of about 471,688 (307)

ZBTB11 Promotes Breast Cancer Progression by Activating FBXO28‐Mediated MST1 Degradation and Suppressing Hippo Signaling

Advanced Science, EarlyView.
ZBTB11 is identified as an oncogenic transcription factor that activates FBXO28 in breast cancer. FBXO28 promotes K48‐linked ubiquitination and degradation of MST1, suppressing Hippo signaling and enhancing epithelial–mesenchymal transition and metastasis. This transcription‐to‐ubiquitination cascade defines a prognostic biomarker axis and highlights a
An Xu, Xiang‐Nan Xu, Xiao Huang, Zhou Luo, Chun‐Lian Li, Yang Du, Cheng Yan, Xiao‐Jie Yu, Jian‐Wen Wang, Long‐Di Yao, De‐Yuan Fu   +10 more
wiley   +1 more source

Disrupting Helicobacter pylori Iron Homeostasis With Bismuth Nanodrug‐Mediated Nutritional Trap for Targeted Gastric Infection Therapy

Advanced Science, EarlyView.
A “nutritional trap” strategy centered on disrupting bacterial iron homeostasis is proposed. The synthesized Bi‐TP@FU (TBF) can target Helicobacter pylori, interfere with the bacterial iron uptake and utilization processes to disrupt its iron homeostasis, induce bacterial death, and meanwhile preserve the balance of the intestinal flora.
Tianye Fang, Jinzhe Tong, Feng Feng, Cong Liu, Chang Shu, Jiaying Zhu, Shibo Zhang, Shuyue Deng, Wanchao Zuo, Yuhan Song, Jun Yang, Yanmin Ju, Yingying Xing, Jianjun Dai   +13 more
wiley   +1 more source

Genetic diversity analysis and core collection construction of tea plant from the Yunnan Province of China using ddRAD sequencing

BMC Plant Biology
Tea plants are economically important woody plants that originated in southwestern China. The Yunnan Province in China is regarded as the central origin of tea plants owing to the abundance and diversity of the tea germplasm present in this region ...
Weihua Sun, Chunlin Chen, Linlin Xu, Lingling Tao, Xiaoyan Tong, Yiping Tian, Huibing Jiang, Linbo Chen, Huilin Wen, Shengrui Liu, Chaoling Wei, Junyan Zhu   +11 more
doaj   +1 more source

Metabolomic and flavoromic insights into the effects of Polygonatum kingianum extract during black tea processing

Frontiers in Nutrition
This study aims to elucidate the effects of the compounding treatment of Polygonatum kingianum extract (PKE) on the sensory quality, flavor chemical characteristics, and potential functional activities of control Dianhong black tea (CK).
Tianyu Wu, Tianyu Wu, Xiaohua Wang, Xiaohua Wang, Xinghua Wang, Xinghua Wang, Junjie He, Junjie He, Wenxia Yuan, Wenxia Yuan, Raoqiong Che, Raoqiong Che, Qiaomei Wang, Qiaomei Wang, Zhie Zhu, Xinya Chen, Xinya Chen, Cangyi Zhao, Chunyan Zhao, Chunyan Zhao, Weihao Liu, Weihao Liu, Chun Wang, Chun Wang, Zejun Wang, Zejun Wang, Hongmei An, Xiujuan Deng, Xiujuan Deng, Baijuan Wang, Baijuan Wang   +30 more
doaj   +1 more source

Ion Superhighways in a Hierarchical Polymer‐Ceramic Membrane Enable Rapid and Selective Lithium Extraction

Advanced Science, EarlyView.
A flexible PDMS‐LATP polymer‐ceramic membrane creates lithium‐ion “superhighways” for rapid and selective extraction from complex brines. The amorphous PDMS matrix suppresses nonselective leakage and stabilizes the ceramic network, while LATP provides preferential Li+ conduction.
Xinxin Wei, Jiawei Sun, Min Wei Boey, Xiaolu Li, Minji Kim, Junghwan Kim, Hongjiang Chen, Patrick H.‐L. Sit, Yixiang Wang, Zhigang Li, Ze‐Xian Low, Jason Chun‐Ho Lam, Alicia Kyoungjin An   +12 more
wiley   +1 more source

TEA at the pictures

, 2017
The Livesey Collection is the most complete assembly of temperance related materials in the world and the lanternslides sit alongside the textual materials as a major part of the temperance movement’s story. Chiefly a campaigning and educational association, the British National temperance league used every technology to promote its message, in working
Mcallister, Annemarie, Cooper, Helen, Kohler, Miriam Grazia maria   +2 more
openaire  

A Sustainable Bio‐Based Epoxy Thermoset as a High‐Performance Alternative to BPA‐Based Resins

Advanced Science, EarlyView.
A rigid–flexible bio‐based epoxy network integrates soybean oil, lignin, and maleic anhydride to overcome the strength–toughness–sustainability trade‐off of conventional BPA epoxy. The thermoset delivers excellent performance as both a structural adhesive and a matrix for glass‐fabric composites, while enabling pH‐responsive degradation, environmental ...
Jiyun Qi, Xinyi Hui, Xipeng Zhang, Jia‐Long Wen, Tong‐Qi Yuan   +4 more
wiley   +1 more source

Targeted Degradation of Picornaviral 3C Protease via PROTACs Confers High Barrier to Viral Resistance and Broad‐Spectrum Antiviral Activity

Advanced Science, EarlyView.
This study reports D34 as the first PROTAC degrader that targets the 3C protease of picornaviruses. D34 effectively degrades EV71 3C protease via the ubiquitin‐proteasome pathway. More importantly, D34 exhibits a high resistance barrier and shows broad‐spectrum antiviral activity against multiple picornaviruses, highlighting its potential as a novel ...
Weilong Deng, Junyu Chen, Yingyue Pang, Yuanyuan Zhang, Siqian Chen, Guoliang You, Xiaoman Tian, Zhongxin Xu, Jing Wang, Luqing Shang   +9 more
wiley   +1 more source

Adaptive Responses of Tropical Crops: A Multi‐Scale Omics Integrated Perspective

Advanced Science, EarlyView.
Tropical crops integrate genomic, morphological, physiological, and ecological adaptations to thrive under extreme and variable environments. This review highlights how natural selection, domestication, and breeding shape stress resilience, resource‐use strategies, and productivity in sugarcane, banana, cassava, rubber and oil palm, offering new routes
Peilin Wang, Chenhui Li, Dongjiao Wang, Qibin Wu, Zhen Zeng, Huiming Guo, Han Cheng, Songbi Chen, Hongxing Cao, Hongmei Cheng, Jianghui Xie, Youxiong Que   +11 more
wiley   +1 more source

Variations of terpenes profiling and functional characterization of terpene synthases in Agrimonia pilosa

BMC Plant Biology
Agrimonia pilosa ledeb, a plant widely distributed in Asia and Europe, is rich in secondary metabolites. It is commonly processed into tea using tender shoots in spring or ustilized as an herb in autumn.
Hui Chen, Guanhua Liu, Qian Wang, Demeng Bao, Yuxi Wang, Fuyin Huang, Han Zhang, Juan Sun, Nuo Wang, Mei Yang, Abdelkader Bassiony, Jianyu Fu   +11 more
doaj   +1 more source