Mechanically Triggered DNA Nanovehicles for Targeted Dual‐Drug Cancer Therapy
A mechanically triggered DNA nanovehicle is introduced that co‐releases two anticancer drugs in response to integrin‐mediated cellular forces. Cholesterol‐anchored DNA assemblies undergo force‐induced unfolding at cell–cell junctions, enabling selective, localized dual‐drug activation in cancer cells while minimizing off‐target toxicity in low‐tension ...
Murali Mohana Rao Singuru +2 more
wiley +1 more source
An associative model of Chinese university teachers' personality traits and students' classroom engagement from the teacher's perspective: the mediating role of emotional regulation. [PDF]
Lu B, Hou W, Sun J, Wang L.
europepmc +1 more source
After spinal cord injury, adult microglia remain persistently activated with chronic PRMT6 (protein arginine methyltransferase 6) upregulation. Prmt6 deficiency or inhibition reestablishes microglial homeostasis and promotes a scar‐limited repairment, enhancing axonal regrowth.
Weilin Peng +9 more
wiley +1 more source
Emotional Intelligence and Teacher Self-Efficacy in Initial Teacher Education: A Psychoeducational Intervention with Spanish Pre-Service Teachers. [PDF]
González-Ros L +3 more
europepmc +1 more source
This study presents an injectable DNA‐based porous hydrogel integrating catechol motifs and targeting aptamers for pulpitis management. Upon in situ crosslinking, the scaffold actively recruits endogenous dental pulp stem cells, restores redox homeostasis, and modulates immune responses.
Luhui Cai +9 more
wiley +1 more source
Exploring Drivers of Children's Food Choices: A Multi-Source Process Evaluation of a School-Based Nutrition Education Program. [PDF]
Jaworski M.
europepmc +1 more source
Phase‐resolved experiments and atomistic simulations reveal asynchronous ordering behaviors in a eutectic high‐entropy alloy during isothermal annealing. Distinct defect transport mechanisms are identified in coexisting B2 and BCC phases, showing that vacancy and interstitial mediated diffusion governs phase‐dependent thermal stability.
Huiwen Yao +5 more
wiley +1 more source
Editorial: Emerging issues in English language education with psycho-emotional traits in the spotlight: futurology in language studies. [PDF]
Barjesteh H +4 more
europepmc +1 more source
A biomimetic, fiber‐reinforced hydrogel (FE‐PDA@Fib/Gel‐TG) that enables dual‐phase cranial defect repair. The system provides: instant hemostasis in the early stage, and sustained co‐delivery of pro‐angiogenic and osteogenic signals for synergistic vascularized bone regeneration.
Lingbin Che +9 more
wiley +1 more source
Using machine learning to predict student mathematics performance in six East Asian countries: evidence from PISA 2022. [PDF]
Djekourmane D +4 more
europepmc +1 more source

