Selective Targeting of Tip Endothelial Cells as a Therapeutic Strategy for Tumor Angiogenesis
Advanced Science, EarlyView.Doppel protein is selectively expressed in tip endothelial cells within the tumor vasculature, where it promotes tip cell motility and stabilizes the tip cell phenotype. Targeting Doppel with monoclonal antibodies disrupts this stabilization, impairs angiogenic sprouting, and reduces tumor angiogenesis, offering a selective and druggable switch for ...
Byoungmo Kim +16 more
wiley +1 more source
Motivating Male Language Learners: The Need for “More Than Just Good Teaching”
Canadian Journal of Applied Linguistics, 2013 Four American boys in an advanced high school French class and their teacher were chosen to participate in a research project. An exploratory case study was then conducted to better understand what motivated these boys to pursue their second language (L2)
Scott Patrick Kissau, Spencer Salas
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A Wearable Brain–Computer Interface for Mitigating Car Sickness via Attention Shifting
Advanced Science, EarlyView.Car sickness poses a major challenge in vehicular travel, yet effective nonpharmacological solutions are scarce. We developed a wearable, closed‐loop mindfulness BCI that uses real‐time EEG‐based neurofeedback to shift attention away from motion‐induced discomfort. Validated in real‐car experiments involving >100$>100$ susceptible individuals, over 83%
Jiawei Zhu +14 more
wiley +1 more source
The role of aggression and maladjustment in the teacher-student relationship on burnout in secondary school teachers. [PDF]
Front Psychol, 2022 Masluk B +6 more
europepmc +1 more source
Advanced Science, EarlyView.This work establishes a standardized, high‐resolution spatial transcriptomics workflow for characterizing host responses to biomaterial implants. Using the 10× Xenium platform, the pipeline integrates spatial mapping, subclustering, and functional enrichment to resolve immune and stromal cell organization at single‐cell resolution, enabling ...
Alex H.P. Chan +7 more
wiley +1 more source
Parental Attachment and Adolescent Moral Reaction Modes: The Serial Mediating Model of the Teacher-Student Relationship and Deviant Peer Affiliation. [PDF]
Psychol Res Behav Manag, 2022 Liu C, Xiao X, Zhan Y.
europepmc +1 more source
Advanced Science, EarlyView.During pupal metamorphosis and starvation, elevated 20‐hydroxyecdysone (20E) and suppressed insulin trigger Forkhead box O (FOXO) nuclear translocation, enhancing miR‐375‐3p expression. This downregulates fatty acid synthase (FASN) and Relish, promoting lipid breakdown for energy while prioritizing antioxidant responses over immune functions to support
Peng Chen +10 more
wiley +1 more source
Learned Conformational Space and Pharmacophore Into Molecular Foundational Model
Advanced Science, EarlyView.The Ouroboros model introduces two orthogonal modules within a unified framework that independently learn molecular representations and generate chemical structures. This design enables flexible optimization strategies for each module and faithful structure reconstruction without prompts or noise.
Lin Wang +8 more
wiley +1 more source
Discovery of H2 Receptor Antagonists as Colistin Enhancers by Targeting Acid Stress Response
Advanced Science, EarlyView.This study identifies YqgB as a key target for restoring colistin susceptibility in mcr‐positive pathogens under acidic conditions by remodeling phospholipid composition and reducing LPS modification. Deep learning‐based screening reveals H2 receptor antagonists as novel colistin adjuvants. Further investigations indicate that ranitidine and famotidine
Jinju Cai +7 more
wiley +1 more source
"It's where learning and teaching begins ‒ is this relationship" - insights on the teacher-student relationship at university from the teachers' perspective. [PDF]
High Educ (Dordr), 2023 Hagenauer G, Muehlbacher F, Ivanova M.
europepmc +1 more source