Results 81 to 90 of about 18,374 (246)

Modifying Glucose Metabolism Reverses Memory Defects of Alzheimer's Disease Model at Late Stages

Advanced Science, EarlyView.
Using spatial transcriptomics, we show that ferul enanthate (SL‐ZF‐01) reverses episodic‐like memory deficits in aged, but not young, Alzheimer’s disease (AD) mice. SL restores glucose metabolism and Glucose Transporter 1/3 expression via an ‘Aging‐AD‐Rescue’ pattern, rescuing deficits seen in aged AD mice.
Fang Liu, Yiyu‐Li Tang, Zong‐Bo Zhang, Ya‐Hong Tan, Si‐Hui Lin, Ni‐Ya Wang, Jin‐Nan Li, Zhi‐Jie Pan, Jian‐Feng Li, Jing‐Fei Huang, Yu‐Qiang Ding, Chun‐Ming Guo, Lin Xu, Cheng Peng, Qi‐Xin Zhou   +14 more
wiley   +1 more source

The IT² Survey: contextual knowledge (XK) influences on teacher candidates' intention to integrate technology. [PDF]

Educ Technol Res Dev, 2021
Foulger TS, Buss RR, Su M.
europepmc   +1 more source

Comprehensive Profiling of N6‐methyladnosine (m6A) Readouts Reveals Novel m6A Readers That Regulate Human Embryonic Stem Cell Differentiation

Advanced Science, EarlyView.
This research deciphers the m6A transcriptome by profiling its sites and functional readout effects: from mRNA stability, translation to alternative splicing, across five different cell types. Machine learning model identifies novel m6A‐binding proteins DDX6 and FXR2 and novel m6A reader proteins FUBP3 and L1TD1.
Zhou Huang, Rucong Liu, Zibaguli Wubulikasimu, Wanqing Zhao, Jiaqi Huang, Jiaxuan Wang, Tianyuan Zhang, Rui Fan, Wei Kong, Qinghua Cui, Yang Li, Yuan Zhou   +11 more
wiley   +1 more source

Examining Field Experiences of Teacher Candidates During COVID-19: Systemic Inequities Unveiled for Underserved English Learners in K-12 Grades. [PDF]

J Hispanic High Educ, 2023
Hernandez AM, Daoud A, Woodcock A, Landin K.   +3 more
europepmc   +1 more source

IGZO‐Based First Spike Timing Tactile Encoders and Coupling‐Enhanced Transistor Synapses for Efficient Spiking Neural Networks

Advanced Science, EarlyView.
Here, a bioinspired light‐accelerated neuromorphic system that seamlessly links tactile sensing, first‐spike‐timing (FST) encoding, and light–electric synaptic learning. Pressure stimuli trigger FST spikes in dual‐gate PDTFTs, while GaOx/IGZO hetero‐synapses exhibit enhanced memory under optical–electrical co‐activation, enabling spiking neural ...
Dan Cai, Jinyong Wang, Tianchen Zhao, Miao Shen, Yunbo Liu, Tieyi Zhang, Fangjie Zhang, Yang Wang, Yadong Jiang, Deen Gu   +9 more
wiley   +1 more source

Small Nucleolar RNA Snord17 Promotes Self‐Renewal of Intestinal Stem Cells through Yy2 mRNA Export and Tead4 Activation

Advanced Science, EarlyView.
Snord17, through interaction with Thoc3, promotes nuclear export and translation of Yy2 mRNA in Snord17+/+ ISCs. The Yy2 protein subsequently binds the Tead4 promoter to promote its transcription, activating Hippo signaling, which is essential for ISC maintenance.
Peikang Zhang, Yuwei Xu, Yufei Lan, Zhen Xiong, Zhibin Yi, Runyuan Wu, Cunzhen Li, Ying Du, Hui Guo, Yingchi Yang, Zusen Fan   +10 more
wiley   +1 more source

Microglial HVCN1 Deficiency Improves Movement and Survival of SOD1G93A ALS Mice by Enhancing Microglial Migration and Neuroprotection

Advanced Science, EarlyView.
Hydrogen voltage gated channel 1 (HVCN1) is upregulated in microglia of both ALS patients and its mouse model. HVCN1 deficiency enhances microglial migration via suppressing Akt signaling, promotes neurotrophic capacity and motor function, and prolongs survival of the SOD1G93A ALS mice. This study identifies HVCN1 as a novel, promising druggable target
Fan Wang, Ke‐Yu Zhang, Lang‐Jian Zhu, Wei‐Jue Li, Yang Wu, Xiang Gao, Xiao‐Ru Ma, Xiu‐Hua Yin, Jian‐Bin Wu, Xiao‐Kang Ye, Zhao‐Jun Dong, Di‐Xian Wang, Zhe Zhou, Shao‐Dong Wang, Lei Han, Zhi‐Nong Jiang, Jing‐Wei Zhao   +16 more
wiley   +1 more source

Examining the Relationships Between Media Literacy, Technology Integration Skills and STEM Applications Self-Efficacy Perception via Structural Equation Model: A Study on Visual Arts Teacher Candidates

International Journal of Modern Education Studies
The purpose of the present study is to examine the relationship between Visual Arts teacher candidates' media literacy, technology integration skills and STEM applications self-efficacy.
Zeliha Canan ÖZKAN
doaj   +1 more source

Construction of PANoptosis‐Inhibiting Carbonized Polymer Dots via Machine Learning Potential for Mitigating Chemodrug‐Induced Nephrotoxicity

Advanced Science, EarlyView.
An enhanced sampling method is developed for molecular dynamics based on trained machine learning force fields to guide the construction of PANoptosis‐inhibiting carbonized polymer dots (Lu‐CDs) derived from a flavonoid compound for treating chemodrug‐induced nephrotoxicity.
Xinchen Liu, Jiaxin Zhang, Xiangyu Yan, Nuo Li, Yu‐Chao Dong, Zihao Wang, Daowei Li, Yong Du, Huan Wang   +8 more
wiley   +1 more source

Multilingual Literacy for All? Aligning Clinical Practice of Bilingual Teacher Candidates in California

Education Sciences
Literacy is at the core of teaching. Teacher candidates in California need to complete a minimum of 400 h of clinical practice, the key component for their training.
Jordi Solsona-Puig, Fernando Rodríguez-Valls   +1 more
doaj   +1 more source