Results 121 to 130 of about 453,390 (310)

CD28‐Targeted Enzyme‐Responsive Conformation‐Switching Peptide Self‐Assembly for Selective T‐Cell Acute Lymphoblastic Leukemia (T‐ALL) Therapy

open access: yesAdvanced Science, EarlyView.
We developed the enzyme‐responsive peptide SAp‐CD28 to selectively target CD28‐overexpressing T‐ALL cells. Following phosphatase‐mediated activation, SAp‐CD28 undergoes conformational switching and nanooligomerization, resulting in the disruption of CD28 downstream signaling.
Jun Li   +10 more
wiley   +1 more source

Preparedness to teach : the perceptions of Saudi female pre-service mathematics teachers : a thesis presented in fulfilment of the requirements for the degree of Doctor of Philosophy in Education at Massey University, Palmerston North, New Zealand [PDF]

open access: yes, 2019
Being well prepared and experiencing a sense of preparedness for teaching is a key learning outcome of any initial teacher education (ITE) program.
Alsaleh, Fatimah Ibrahim
core  

Generation of CCR4/CD7 Bispecific CAR‐T Cells Resistant to Fratricide and Exhaustion

open access: yesAdvanced Science, EarlyView.
The applications of CAR T‐cell therapy in T‐cell malignancies face limitations such as fratricide, effector‐cell exhaustion, and antigen‐escape. Herein, we developed fratricide‐ and exhaustion‐resistant CAR‐T cells that targeted CCR4 and CD7 simultaneously, with optional EGFRt safety switch. Additionally, scRNA‐seq unveiled new molecular targets, which
Sile Li   +10 more
wiley   +1 more source

Relationship between Classroom Climate, Student Self-Efficacy, and Achievement in the High School Math Classroom [PDF]

open access: yes, 2014
There is a variety of past research regarding the relationship between the mathematics classroom climate and student learning. More specifically, many studies look at how the classroom climate may influence student self-efficacy in math.
Carr, Delaney
core   +1 more source

Tumor‐Derived Exosomal TAGLN2 Promotes Metastasis by Inducing Vascular Permeability and Angiogenesis via the NRP1/SEMA4D/YAP Axis

open access: yesAdvanced Science, EarlyView.
Gastric cancer‐derived exosomal TAGLN2 is identified as a key mediator of vascular reprogramming, with significantly elevated levels detected in patient serum. Independent of canonical SEMA4D signaling, it nucleates a cytoplasmic TAGLN2/NRP1/SEMA4D ternary complex that dually activates YAP, promoting angiogenesis, vascular dysfunction, and metastasis ...
Shuqi Yu   +7 more
wiley   +1 more source

Self-efficacy beliefs in pre-service chilean english teachers [PDF]

open access: yes, 2015
Tesis (Profesor de Inglés para la Enseñanza Básica y Media y al grado académico de Licenciado en Educación)This research study investigated Chilean pre-service teachers of English.
Alvear Concha, Valentina   +4 more
core  

Multifunctional Bioactive Scaffold Facilitating BMSCs‐Driven Osteogenesis and Vascularization in Critical‐Sized Bone Defect Repair

open access: yesAdvanced Science, EarlyView.
A dual‐network bFGF@CB‐gel integrates: i) ChSMA scaffold (mechanical support/BMSCs delivery); ii) BC carrier (sustained bFGF release via EGFL/Itga2b and COMP/PI3K/AKT for adhesion/osteogenesis); iii) bFGF/PI3K/AKT/eNOS for angiogenesis. This rational, synergistic design addresses CSD bone regeneration challenges.
Yunze Feng   +12 more
wiley   +1 more source

Öğretmen Adaylarının Kişilerarası İletişim Yetkinlikleri ile Öğretmen Özyeterlikleri Arasındaki İlişkide Öğrenme Çevikliğinin Aracı Rolü

open access: yesVan Yüzüncü Yıl Üniversitesi Eğitim Fakültesi Dergisi
Bu Çalışmanın amacı öğretmen adaylarının kişisel iletişim yetkinlikleri, öğretmen özyeterlikleri ve öğrenme çevikliği arasındaki yapısal ilişkilerin incelenmesidir. Bu ilişkisel araştırmanın katılımcılarını 449 öğretmen adayı oluşturmuştur.
F. Özge Maviş Sevim   +1 more
doaj   +1 more source

Are Leader Behavior and Emotional Intelligence related to Teacher Efficacy? [PDF]

open access: yes, 2018
There is general agreement and the research supports the contention that school leadership is related to student learning/achievement (Hallinger & Heck, 1996; Ross & Gray, 2006; Francera & Bliss, 2011; Shatzer, Caldarella, Hallam, & Brown, 2014). However,
Leonard, Edward E, Maulding Green, Wanda
core   +2 more sources

Home - About - Disclaimer - Privacy