Results 131 to 140 of about 453,390 (310)

NQO1‐Mediated Anoikis Resistance and Immune Evasion Define a High‐Risk Multi‐Omic Subtype for Precision Management of T1 High‐Grade Bladder Cancer

open access: yesAdvanced Science, EarlyView.
Multi‐omic profiling of T1 high‐grade bladder cancer identifies a high‐risk subtype (T1HG1) driven by NQO1, which couples anoikis resistance with immune evasion. NQO1 orchestrates macrophage–T cell crosstalk suppression via CXCL9 modulation. Pharmacological NQO1 inhibition with skullcapflavone II enhances cisplatin efficacy, representing a promising ...
Bin Guo   +20 more
wiley   +1 more source

Tumor‐Induced Splenic Remodeling: Mechanisms of Systemic Immunosuppression and Emerging Therapeutic Opportunities

open access: yesAdvanced Science, EarlyView.
ABSTRACT Despite the transformative impact of cancer immunotherapies such as immune checkpoint blockade, durable clinical responses remain limited. Increasing evidence indicates that antitumor immunity is governed not only by the tumor microenvironment, but also by systemic immune regulation mediated by peripheral immune organs. Among these, the spleen
Yuehua Liu, Xiaoqian Nie, Xiaofei Gao
wiley   +1 more source

Teachers' self-efficacy in teaching family life education [PDF]

open access: yes, 2014
Although the notion of self-efficacy has been applied to many domains, little is known regarding teacher efficacy in teaching family life. Self-efficacy in this study refers to teachers' beliefs that their efforts can improve students' moral characters ...
Abu, Rosini   +3 more
core  

Mechanisms of Pericyte‐Mediated Cancer Metastasis

open access: yesAdvanced Science, EarlyView.
Pericytes play multifarious roles in promoting cancer metastasis by facilitating metastatic cancer cell dissemination, circulating tumor cell survival, tissue extravasation, premetastatic niche formation, and metastatic tumor growth. These cells have intertwined interactions with vascular endothelial cells to modulate cancer cell behavior and ...
Ziheng Guo, Yihai Cao
wiley   +1 more source

Mechanically Triggered DNA Nanovehicles for Targeted Dual‐Drug Cancer Therapy

open access: yesAdvanced Science, EarlyView.
A mechanically triggered DNA nanovehicle is introduced that co‐releases two anticancer drugs in response to integrin‐mediated cellular forces. Cholesterol‐anchored DNA assemblies undergo force‐induced unfolding at cell–cell junctions, enabling selective, localized dual‐drug activation in cancer cells while minimizing off‐target toxicity in low‐tension ...
Murali Mohana Rao Singuru   +2 more
wiley   +1 more source

An Analysis of Teacher Efficacy and Perspectives about Elementary Literacy Instruction

open access: yesCurrent Issues in Education, 2013
At the core of every teacher is a set of beliefs and knowledge regarding teaching and learning. As a teacher develops her expertise, curricular practices are refined and self-efficacy is enhanced.
Joy Abernathy-Dyer   +2 more
doaj  

Efficacy of the teachers committee meetings based on teachers’ views

open access: yesİnönü Üniversitesi Eğitim Fakültesi Dergisi, 2008
This study intends to determine the efficacy of teachers? committee meetings based on the views of high school teachers To realize this aim ?Teachers Committee Meeting Evaluation Scale? developed by the researchers was given to a total of 276 high school teachers F=105 M=171 According to the results it was found that the teachers evaluated these ...
DEMİRTAŞ, Hasan   +3 more
openaire   +2 more sources

Prmt6 Deficiency or Inhibition Restores Microglial Homeostasis and Promotes Scar‐Limited Repair in Adult Spinal Cord Injury

open access: yesAdvanced Science, EarlyView.
After spinal cord injury, adult microglia remain persistently activated with chronic PRMT6 (protein arginine methyltransferase 6) upregulation. Prmt6 deficiency or inhibition reestablishes microglial homeostasis and promotes a scar‐limited repairment, enhancing axonal regrowth.
Weilin Peng   +9 more
wiley   +1 more source

The Impact of School Culture on Teacher Efficacy through Teacher Leadership as an Intervening Variable in Regents Secondary School Bali

open access: yesKelola: Jurnal Manajemen Pendidikan
Teacher efficacy is a central aspect of education that reflects a teacher's belief in their ability to influence student learning outcomes. A conducive school culture, including commitment and collegial support, plays an important role in strengthening ...
Yoel Agung Budiarto   +2 more
doaj   +1 more source

Pengaruh Kecerdasan Emosional, dan Self Efficacy terhadap Kinerja Guru Matematika [PDF]

open access: yes, 2019
The research was purpose to understand the relationship between emotional intelligence self-efficacy and job performance math teacher. The method was conducted by survey research.
Gusri, S. A. (Sandra)   +2 more
core  

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