Results 131 to 140 of about 1,823,256 (304)

Neuid: A Novel Neuron‐Enriched LncRNA that Connects Epigenetic Gene Silencing to Alzheimer's Disease

open access: yesAdvanced Science, EarlyView.
ABSTRACT The increasing evidence that non‐coding RNAs can become deregulated during pathogenesis is dramatically expanding the space for drug discovery beyond the protein‐coding genome. Long noncoding RNAs (lncRNAs) are emerging as key regulators of cellular function, yet most remain uncharacterized.
Ranjit Pradhan   +17 more
wiley   +1 more source

Early childhood teachers’ perceptions of their knowledge base for facilitating the teaching of science concepts

open access: yesPrometeica
Teachers’ knowledge of subject matter is critical in effectively shaping their ability to facilitate science concepts to young learners. However, early childhood education faces unique challenges, and research examining how teachers perceive their ...
Mamontsuoe Lintle Maraisane
doaj   +1 more source

Machine Learning for Green Solvents: Assessment, Selection and Substitution

open access: yesAdvanced Science, EarlyView.
Environmental regulations have intensified demand for green solvents, but discovery is limited by Solvent Selection Guides (SSGs) that quantify solvent sustainability. Training a machine learning model on GlaxoSmithKline SSG, a database of sustainability metrics for 10,189 solvents, GreenSolventDB is developed. Integrated with Hansen solubility metrics,
Rohan Datta   +4 more
wiley   +1 more source

Knowledge teachers in teacher's counters understanding

open access: yesRevista Ibero-Americana de Estudos em Educação, 2016
The central objective of the study was to analyze the understanding of teacher’s counters on the knowledge teachers who contribute to the process of teaching and learning. The study was characterized as descriptive research, conducted through semi-structured interviews and qualitative data analysis.
Cristian Baú Dal Magro   +2 more
openaire   +1 more source

A Perspective on Interactive Theorem Provers in Physics

open access: yesAdvanced Science, EarlyView.
Into an interactive theorem provers (ITPs), one can write mathematical definitions, theorems and proofs, and the correctness of those results is automatically checked. This perspective goes over the best usage of ITPs within physics and motivates the open‐source community run project PhysLean, the aim of which is to be a library for digitalized physics
Joseph Tooby‐Smith
wiley   +1 more source

Transforming epistemological invisibility: (re)claiming intercultural learning within an ESOL teacher education programme [PDF]

open access: yes
This paper analyses critiques, shared by first generation migrant ESOL(English for Speakers of Other Languages) teacher ‘trainees’, on officially validated dominant perceptions of professional competency and identity within an ESOL teacher education ...
Chopra, Priti
core  

SMAD4 Palmitoylation Drives a Metabolic‐Transcriptional Circuit to Promote Tumorigenesis and Confers Radiosensitivity in Pancreatic Cancer

open access: yesAdvanced Science, EarlyView.
This study identifies palmitoylation as a novel regulatory modification of SMAD4, mediated by ZDHHC22/APT2. It activates fatty acid synthesis, creating a self‐reinforcing SMAD4–FASN–palmitate feedback loop that drives pancreatic cancer growth and enhances radiotherapy sensitivity.
Yang Wang   +16 more
wiley   +1 more source

Building cliniciansʼ teacher knowledge

open access: yesAcademic Medicine, 1996
P, Lye, D, Simpson, K, Wendelberger
openaire   +3 more sources

An Activity‐Dependent NEPAS–PTX3 Axis Links Neurovascular and Myelin Deficits to Cognitive Impairment

open access: yesAdvanced Science, EarlyView.
An activity‐dependent pathway links prefrontal circuit hypoactivity to cognitive impairment. Reduced PVA–mPFC activity upregulates NEPAS, which suppresses PTX3 secretion, leading to impaired angiogenesis, myelin deficits, and memory decline. Rescue is achieved by NEPAS knockdown or chemogenetic circuit activation.
Boya Hu   +11 more
wiley   +1 more source

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