Results 241 to 250 of about 8,858,846 (348)

Identifying Cytokine Motif‐Containing, Immunomodulatory Bacterial Proteins in Human Gut Microbiome

Advanced Science, EarlyView.
By building and constructing HMM (Upper left, blue), the authors identify CMCPs in bacteria genomes and CRC related metagenomes and enriched CRC‐related CMCPs (Upper right, blue). They analyze sequence and structural similarity of hits (Lower left, green), test function with engineered EcN delivered to tumors in a mouse tumor model (Lower right, pink ...
Ziyu Wang, Siqi Guo, Jing Li, Qianqian Huang, Jing Ning, Binbin Xia, Xun Lv, Xiang Liu, Zeyu Gao, Jine Li, Longchao Liu, Moshi Song, Jun Wang   +12 more
wiley   +1 more source

Script or style? Analysis of the relationship between teaching scripts and supervision style. [PDF]

PLoS One
Sader J, Bajwa NM, Lüchinger R, Fassier T, Audétat MC, Nendaz M, Junod Perron N.   +6 more
europepmc   +1 more source

Mechanical Strain‐Programmed SDC1+ Sheath Fibroblasts Trigger CXCR4hi Neutrophil‐Mediated Enthesitis in Ankylosing Spondylitis

Advanced Science, EarlyView.
In ankylosing spondylitis (AS), mechanical strain‐programmed SDC1+ sheath fibroblasts secrete CXCL5 to recruit neutrophils and promote the activation of CXCR4hi neutrophils, thereby exacerbating enthesitis by promoting neutrophil extracellular traps (NETs) formation. SOX5 controls the generation of SDC1+ sheath fibroblasts via super‐enhancers.
Jiajie Lin, Zepeng Su, Yipeng Zeng, Yi Zhou, Chenying Zeng, Weihao Zhang, Qibo Li, Zipeng Xiao, Zibin Chen, Ziqian Liu, Yangfeng Lin, Guan Zheng, Wenhui Yu, Zhongyu Xie   +13 more
wiley   +1 more source

Intraoperative Discovery and Laparoscopic Management of a Cholecystocolonic Fistula: A Case Report. [PDF]

Cureus
Mridha S, Hewitt A, Khetan N.
europepmc   +1 more source

Integrating Spatial Proteogenomics in Cancer Research

Advanced Science, EarlyView.
Xx xx. ABSTRACT Background: Spatial proteogenomics marks a paradigm shift in oncology by integrating molecular analysis with spatial information from both spatial proteomics and other data modalities (e.g., spatial transcriptomics), thereby unveiling tumor heterogeneity and dynamic changes in the microenvironment.
Yida Wang, Yang Wu, Feng Zhang, Parthiban Periasamy, Haiyue You, Denise Goh, Rachel Elizabeth Ann Fincham, Xin Ning, Danping Wu, Lu Liu, Ying Jiang, Zhiwen Qian, Joe Yeong, Yan Zhang   +13 more
wiley   +1 more source

Application of scenario simulation based on boppps model in physical diagnostics--a practical exploration of integrated teaching mode for cardiac physical examination and electrocardiogram. [PDF]

BMC Med Educ
Wu B, Chen T, Mei X, Yue W, Wang D, Xu M, Dong Y, Hu Z, Ying M.   +8 more
europepmc   +1 more source

A Scalable Framework for Comprehensive Typing of Polymorphic Immune Genes from Long‐Read Data

Advanced Science, EarlyView.
SpecImmune introduces a unified computational framework optimized for long‐read sequencing to resolve over 400 highly polymorphic immune genes. This scalable approach achieves high‐resolution typing, enabling the discovery of cross‐family co‐evolutionary networks and population‐specific diversity.
Shuai Wang, Xuedong Wang, Mengyao Wang, Qian Zhou, Lusheng Wang, Shuai Cheng Li   +5 more
wiley   +1 more source

Situational simulation teaching can effectively enhance the clinical thinking ability of residents. [PDF]

BMC Med Educ
Meng J, Wang L, Jin D, Li Z, Tao Q, Ying L.   +5 more
europepmc   +1 more source

The Age‐Dependent Resident Myonuclear Multi‐Omic Response to an Acute Skeletal Muscle Hypertrophic Stimulus in Mice

Advanced Science, EarlyView.
Resident myonuclei are the molecular “control centers” for large multinuclear muscle fibers. It is presumed that, with aging, these control centers become compromised and contribute to delayed or blunted muscle adaptive potential. This study is a detailed roadmap that exposes how young versus aged myonuclei respond to a hypertrophic loading stimulus ...
Pieter J. Koopmans, Ronald G. Jones III, Ana Regina Cabrera, Francielly Morena, Nicholas P. Greene, John J. McCarthy, Ahmed Ismaeel, Yuan Wen, Kevin A. Murach   +8 more
wiley   +1 more source

Comparison of Online-to-Offline Teaching Rounds and Bedside Teaching Rounds in Nephrology Residency Training. [PDF]

Adv Med Educ Pract
Han B, Yang F, Yang M, Yang Q, Xiong Y, Ma K.   +5 more
europepmc   +1 more source