Results 111 to 120 of about 2,260,845 (299)
Molecular Oncology, EarlyView.The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim +17 more
wiley +1 more source
Mode coupling trigger of neoclassical magnetohydrodynamic tearing modes in tokamaks
, 1997 Numerical studies of the nonlinear evolution of coupled magnetohydrodynamic - type tearing modes in three-dimensional toroidal geometry with neoclassical effects are presented.
Gianakon, T. A. +2 more
core +1 more source
Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation
Molecular Oncology, EarlyView.How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim +11 more
wiley +1 more source
Frontiers in PhysicsThis paper reviews the recent advancements of the algorithm and application to fusion plasma instability study of the fully kinetic Particle-in-Cell (PIC) method.
Jincai Ren, Giovanni Lapenta
doaj +1 more source
Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer
Molecular Oncology, EarlyView.Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba +5 more
wiley +1 more source
Tearing Mode Instability due to Anomalous Resistivity
Tearing mode instability in the presence of microscopic turbulence is investigates. The effects of microscopic turbulence on tearing mode are taken as drags which are calculated by one-point renormalization method and mean-field approximation.
ITOH, Sanae-I. +4 more
core
Numerical modeling of linear drift-tearing mode stability
, 2003 Numerical modeling results of the linear drift tearing modes are presented. The present model is based on the two-fluids equations, and the perturbed bootstrap current is also included.
Günter, S., Yu, Q., Scott, B.
core
An innovative interpretation of rotating tearing mode locking to an external static current
, 2001 Naturally occurring error elds in tokamaks, which arise from misalignments of the external eld coils, may trigger the onset of tearing modes. The conditions under which a static error eld is able to lock a rotating tearing mode and how this process ...
Coelho R, Lazzaro E
core +1 more source
Spatial heterogeneity of hotspot mutations and clonal relatedness in ovarian endometrioid carcinoma
Molecular Oncology, EarlyView.Spatially resolved analysis revealed heterogeneous distributions of selected cancer‐associated mutations within ovarian endometrioid carcinomas. Shared mutations between paired endometrial and ovarian tumors supported clonal relatedness. These findings highlight the value of sampling multiple tumor regions when interpreting molecular profiles ...
Takahito Ashihara +10 more
wiley +1 more source
The Astrophysical JournalWe investigate the development of tearing-mode instability using the highest-resolution 2D magnetohydrodynamic simulations of reconnecting current sheets performed on a uniform grid, for Lundquist numbers of 10 ^3 ≤ S ≤ 5 × 10 ^5 , reaching up to 65,536 ^
Giovani H. Vicentin +3 more
doaj +1 more source