Results 121 to 130 of about 15,629 (230)

PKA‐Mediated Proteasome Activation Protects Against Cardiac Remodeling and Heart Failure During Systolic Overload

The FASEB Journal, Volume 40, Issue 15, 15 August 2026.
Systolic overload increases the synthesis of cardiac proteins, both misfolded and native, leading to cardiac hypertrophy and elevated proteostasis burden. Meanwhile, systolic overload also increases Ser14‐RPN6 phosphorylation (pS14‐RPN6), thereby increasing proteasome (Psm) proteolytic capacity and meeting the increased demand for protein degradation ...
Md. Salim Ahammed, Penglong Wu, Yifan Wang, Liuqing Yang, Jack O. Sternburg, Faqian Li, Jinbao Liu, Xuejun Wang   +7 more
wiley   +1 more source

Therapeutic manipulation and spatial quantification of the tumor microenvironment in colorectal cancer. [PDF]

iScience
Mulholland-Illingworth EJ, Moore JW, Lin M, Amirkhah R, Grzesiak L, Ligeza A, Bull JA, Boen J, Valbuena GN, Gillespie MA, Lannagan TRM, Gilroy K, Mills ML, Corry SM, Ridgway RA, Belnoue-Davis HL, Dunne PD, Sansom OJ, Byrne HM, Leedham SJ.   +19 more
europepmc   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, Volume 20, Issue 8, Page 1933-1962, August 2026.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

Identifying Plasma Biomarkers That Predict Patient-Reported Outcomes Following Treatment for Trapeziometacarpal Osteoarthritis Using Machine Learning. [PDF]

Int J Mol Sci
Maniglio M, Saggaf M, Purohit N, Antflek D, Rockel JS, Kapoor M, Baltzer HL.   +6 more
europepmc   +1 more source

The Host Cell Factor Phosphatase‐2A Subunit PR130 Restricts Replication of Herpes Simplex Virus Type‐1

Advanced Science, Volume 13, Issue 44, 7 August 2026.
Molecular, genetic, virological, and biochemical analysis in combination with global proteome and phosphoproteome profiling and functional assays were applied to study the role of PR130 in the context of HSV‐1 replication. The observations reveal that host‐intrinsic mechanisms regulate HSV‐1 replication and highlight PR130 as a susceptibility factor of
Johannes Jungwirth, Christoph F. Jacob, Alexandra Nguyen, Mandy Beyer, Andreas O. Mieland, Mario Dejung, Jia‐Xuan Chen, Walburgis Brenner, Christina Ehrhardt, Andreas Henke, Oliver H. Krämer   +10 more
wiley   +1 more source

Ageing-related structural and cellular alterations in the mouse muscle-tendon junction. [PDF]

Biogerontology
Thorpe CT, Iwasaki N.
europepmc   +1 more source

Stage‐Specific H3K14 and H3K23 Succinylation Orchestrates Insect Metamorphosis and Oogenesis

Advanced Science, Volume 13, Issue 43, 3 August 2026.
Stage‐specific succinylation of histone H3 at lysine 14 and 23 differentially controls insect metamorphosis and oogenesis through distinct GPCR‐PKC signaling cascades, revealing an evolutionarily conserved epigenetic mechanism that coordinates key life‐history traits.
Yu‐Pu Jing, Lunjie Li, Libin Yang, Lin‐Jie Zhang, Qiang Yan, Ci Zhang, Zanrong Wen, Guangze Yu, Qian Li, Shutang Zhou   +9 more
wiley   +1 more source

Establishment of Patient-Derived Organoids from Hepatocellular Carcinoma: Preliminary Data on Yield, Histopathological Concordance, and Methodological Challenges. [PDF]

Cells
Lo Re O, Corti C, Cerrito L, Cesari E, Creta E, De Maio F, Di Prima A, Facciuto V, Ferraro C, Huqi E, Liotta R, Lo Pinto M, Pagano D, Perriera R, Petito V, Santarelli G, Santopaolo F, Stella L, Tortomasi F, Sette C, Gruttadauria S, Giuliante F, Zito G, Ponziani FR.   +23 more
europepmc   +1 more source

Field‐Deployable FTA Card for Sampling, Storage and Detection of Aeromonas spp. in Rainbow Trout: Four‐Year Ambient DNA Stability Validated

Aquaculture, Fish and Fisheries, Volume 6, Issue 4, August 2026.
ABSTRACT Bacterial pathogen detection in rainbow trout (Oncorhynchus mykiss, Walbaum 1792) aquaculture typically involves multi‐step procedures, including sample transport, bacterial isolation, culture and subsequent molecular analysis. Aeromonas salmonicida and Aeromonas hydrophila are major pathogens causing significant losses; however, conventional ...
İfakat Tülay Çağatay
wiley   +1 more source

Techne

Journal of Esoteric Buddhism, 1962
openaire   +2 more sources