Results 141 to 150 of about 19,007 (252)

Impact of non‐genetic heterogeneity of BRAF‐mutant colon cancer organoids on growth kinetics, drug sensitivity and Wnt dynamics

International Journal of Cancer, Volume 159, Issue 2, Page 490-500, 15 July 2026.
What's new? Patient‐derived organoids (PDOs) model tumor biology and drug response while preserving key tumor features, yet the impact of non‐genetic culture variables is poorly understood. This study examined the influence of organoid size, seeding density, and morphology on growth, drug sensitivity, and Wnt signaling in a colorectal cancer organoid ...
Viktoria Zieger, Ellen Woehr, Jasmin Traichel, Tilman Brummer, Roland Zengerle, Sabrina Kartmann, Stefan Zimmermann   +6 more
wiley   +1 more source

NRASQ61R Expression in Lymphatic Endothelial Cells Causes Enlarged Vessels, Hemorrhagic Chylous Effusions, and High Mortality in a Mouse Model of Kaposiform Lymphangiomatosis

Pediatric Blood &Cancer, Volume 73, Issue 7, July 2026.
ABSTRACT Background Kaposiform lymphangiomatosis (KLA) is an aggressive complex lymphatic anomaly. Patients exhibit malformed lymphatic vessels and often develop hemorrhagic effusions and elevated angiopoietin‐2 (Ang‐2) levels. A somatic NRAS p.Q61R (NRASQ61R) mutation has been associated with KLA.
C. Griffin McDaniel, Patricia Pastura, Joshua P. Scallan, Timothy D. Le Cras   +3 more
wiley   +1 more source

Konstens arete : Techne som dygd hos Platon i Den Mindre Hippias och Gorgias

, 2018
The most common question that scholars ask regarding the concept of techne in the Plato dialogues is if it is possible to understand arete, morale or the good, as a techne, that is, if arete kan be viewed as a knowledge, an ability or a skill.
Hildeman Togner, Theodor
core   +1 more source

P585: Amplification-based nanopore sequencing accurately detects HBA and HBB SNVs, indels, and structural variants in clinical thalassemia samples

Genetics in Medicine Open
Jaime Lopes, Marcus Cannon, Jonathan Turner, Monica Roberts, Theodore Markulin, Christopher Fraher, Bryan Killinger, Stela Filipovic-Sadic, Bradley Hall   +8 more
doaj   +1 more source

Plasma Aryl Hydrocarbon Receptor Agonist Activity Is Associated With Inflammation and Metabolic Dysregulation in Obesity: A Cross‐Sectional Study

Diabetes/Metabolism Research and Reviews, Volume 42, Issue 5, July 2026.
ABSTRACT Background The aryl hydrocarbon receptor (AhR) is linked to inflammation, but its plasma agonist activity and association with metabolic and inflammatory markers in obesity remain unclear. This cross‐sectional study aimed to determine the level of plasma AhR agonistic activity and its association with systemic inflammation and metabolic ...
Fatemah Bahman, Shihab Kochumon, Ashraf Al Madhoun, Areej Al‐Roub, Abdullah Bennakhi, Monira Arouj, Fahd Al‐Mulla, Rasheed Ahmad   +7 more
wiley   +1 more source

Methionine Synthase Interacts With the Methionine Adenosyl‐Transferase MATα2 and the DNA Methyltransferase DNMT3b in the Nucleus

Journal of Inherited Metabolic Disease, Volume 49, Issue 4, July 2026.
This study shows that methionine synthase (MS) interacts with MATα2, responsible for SAM production, and the methyltransferase DNMT3b in the nucleus. These results support the idea that spatial compartmentalization of one‐carbon metabolism could play a major role in regulating the epigenome.
Manon Jeandel, Jean‐Marc Alberto, Okan Baspinar, Aurélie Robert, Natacha Dreumont, Zeinab Alsahly, David Meyre, Jean‐Louis Guéant, David Coelho   +8 more
wiley   +1 more source

Spatial Protein Expression Analysis in Lungs Using Capillary-Based Immunoassay After Laser-Assisted Microdissection. [PDF]

Cells
Hadzic S, Gredic M, Nebel V, Weissmann N, Wu CY.   +4 more
europepmc   +1 more source

Clinical Trial: Predicting Response to Iron Therapy in Patients With Active Inflammatory Bowel Disease Using Hepcidin and Functional Iron Indices: A Multicentre Randomised Trial

Alimentary Pharmacology &Therapeutics, Volume 64, Issue 2, Page 166-176, July 2026.
Hepcidin levels predict response to iron therapy and support route selection for iron therapy in patients with active inflammatory bowel disease: higher levels favour IV iron, while lower levels indicate likely oral response. Ferritin‐based indices, particularly transferrin/log10(ferritin) and sTfR/log10(ferritin), offer reliable alternatives. ABSTRACT
Lola J. M. Koppelman, Roberta Loveikyte, Rogier L. Goetgebuer, Sander van der Marel, Annemarie C. de Vries, Gerard Dijkstra, Andrea E. van der Meulen‐de Jong, on behalf of the Dutch Iron Study Group, M. Duijvestein, M. van der Have, C. Horjus, W. G. N. Mares, Z. Mujagic, B. Oldenburg, R. West   +14 more
wiley   +1 more source

VII National Seminar of Monument Protection Law for young scientists, doctoral students and students of Professor Jan Pruszyński, Lubostroń, September 17–19, 2020

, 2020
Schatt-Babińska, Katarzyna
core   +1 more source

Evidence that 5‐HT2A receptor signalling efficacy and not biased agonism differentiates serotonergic psychedelic from non‐psychedelic drugs

British Journal of Pharmacology, Volume 183, Issue 14, Page 4058-4071, July 2026.
Background and Purpose Serotonergic psychedelic drugs are under investigation as therapies for various psychiatric disorders, including major depression. Although serotonergic psychedelic drugs are 5‐HT2A receptor agonists, some such agonists are not psychedelic, potentially due to differences in 5‐HT2A receptor ligand bias or signalling efficacy. Here,
Aurelija Ippolito, Sridhar Vasudevan, Shaun Hurley, Gary Gilmour, Frederick Westhorpe, Grant Churchill, Trevor Sharp   +6 more
wiley   +1 more source