Results 131 to 140 of about 15,629 (230)

High Expression of SSEA3 and Globo H Predicts Poor Outcomes in Resected Extrahepatic Cholangiocarcinoma: A Single‐Center Retrospective Cohort Study

open access: yesCancer Medicine, Volume 15, Issue 8, August 2026.
ABSTRACT Background SSEA3, SSEA4, and Globo H glycosphingolipids have been implicated in tumor progression and immune modulation across various malignancies. However, their clinical significance in extrahepatic cholangiocarcinoma (eCCA) remains largely undefined.
Tsai‐Hsien Hung   +6 more
wiley   +1 more source

Mycoplasma Contamination Alters the Expression Profile of Pro‐Inflammatory Cytokines by Human Innate Immune Cells

open access: yesCell Biochemistry and Function, Volume 44, Issue 8, August 2026.
ABSTRACT The impact of Mycoplasma contaminations on in vitro test systems has been extensively discussed and in vitro studies have demonstrated various effects on the physiology of the contaminated cell line. Thus far, little is known about the effect of biologically active substances, such as viruses produced in contaminated cell lines on primary ...
Patricia Gogesch   +5 more
wiley   +1 more source

ADAMTS4 mediates LPS‐induced cardiac injury and myocardial fibrosis through proteolytic cleavage of TSP1

open access: yesClinical and Translational Medicine, Volume 16, Issue 8, August 2026.
• ADAMTS4 is induced primarily in cardiac fibroblasts during sepsis. • ADAMTS4 cleaves TSP1 at the 236–246 aa functional region. • TSP1 cleavage activates TGF‐β/Smad and NF‐κB signalling in fibroblasts. • Targeting ADAMTS4 reduces fibroblast activation and cardiac fibrosis.
Zhe‐Wei Zhang   +12 more
wiley   +1 more source

A skeletal muscle atlas shows neuromuscular junction adaptations to growth and atrophy. [PDF]

open access: yesDev Cell
Campanario S   +26 more
europepmc   +1 more source

DNA Hypomethylation Is Not Cell Intrinsically Toxic to Polycomb Repressive Complex 2 Deficient Malignant Peripheral Nerve Sheath Tumors

open access: yesGenes, Chromosomes and Cancer, Volume 65, Issue 8, August 2026.
ABSTRACT Malignant peripheral nerve sheath tumors (MPNSTs) are aggressive soft tissue sarcomas and the most common cause of disease‐associated death for neurofibromatosis type 1 (NF1) patients. In the context of NF1, MPNSTs develop from benign premalignant precursors and the transition to malignancy is typically accompanied by loss of the polycomb ...
Madilyn R. Stahl   +4 more
wiley   +1 more source

Chondroid Soft Tissue Tumors With FOS::PABPN1 Fusion: A New Entity? About Two Cases

open access: yesGenes, Chromosomes and Cancer, Volume 65, Issue 8, August 2026.
ABSTRACT Soft tissue tumors with chondroid matrix represent a heterogeneous group with persistent diagnostic challenges. Advances in molecular diagnostics have identified recurrent gene fusions in several chondroid neoplasms, predominantly involving FN1. Here, we report two cases of chondroid tumors harboring a novel FOS::PABPN1 fusion.
Jinane Kharmoum   +7 more
wiley   +1 more source

Development of autologous in vitro vascular models for use in preclinical biotherapeutic development. [PDF]

open access: yesBlood Vessel Thromb Hemost
Lund E   +7 more
europepmc   +1 more source

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