Results 11 to 20 of about 15,629 (230)

A proof-of-concept analysis of carbohydrate-deficient transferrin by imaged capillary isoelectric focusing and in-capillary immunodetection

open access: yesBioTechniques, 2020
Carbohydrate-deficient transferrin (CDT) is a reliable biomarker for chronic alcohol abuse. We developed a method for CDT analysis by capillary isoelectric focusing, followed by immunodetection directly in the capillary, in an automated fashion and on a ...
Jiaqi Wu   +3 more
doaj   +1 more source

The hidden foundation of polis in Hobbes's theory of liberalism [PDF]

open access: yesSociološki Pregled, 2021
In the article the author reflects upon the issue of the basis of Hobbes's theory of liberalism i.e. examines the way how a par excellence theory of Modernity shifts from being a political ontology into apolitical haunt logy proper.
Koljević-Grifit Bogdana N.   +1 more
doaj   +1 more source

The limits of techne and episteme [PDF]

open access: yesAnnals of Emergency Medicine, 2004
Annals of Emergency Medicine 43 (2004) 15-16.
Center for Safety in Emergency Care and the Department of Emergency Medicine, University of Florida Health Science Center, Jacksonville, FL, USA ( host institution )   +1 more
openaire   +2 more sources

Spiritual Exercise as Techne: Philosophy as a Way of Liberating Education

open access: yesRUDN Journal of Philosophy, 2021
The study of education systems as social phenomena has led scholars to question the role of education in modern society. The question of how to improve education naturally leads to concerns about what is wrong with the present education system.
Shu-Fen Lin   +2 more
doaj   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

open access: yesMolecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska   +13 more
wiley   +1 more source

A Novel Recombinant Vitronectin Variant Supports the Expansion and Differentiation of Pluripotent Stem Cells in Defined Animal-Free Workflows

open access: yesCells
An essential aspect of harnessing the potential of pluripotent stem cells (PSCs) and their derivatives for regenerative medicine is the development of animal-free and chemically defined conditions for ex vivo cultivation.
Xi Lu   +8 more
doaj   +1 more source

Elenchtike techne, erotike techne: in margine al Carmide platonico

open access: yesPlato, 2020
The paper aims to investigate the relationship between ἐρωτικὴ τέχνη and ἐλεγκτικὴ τέχνη in Plato’s early dialogues, and especially in the Charmides, through a close exam of the role of ἀντέρως in the dialogical practice and exchanges.
Francesca Pentassuglio
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

open access: yesMolecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka   +9 more
wiley   +1 more source

Engineering Pluripotent Stem Cells‐Derived Inner Ear Organoids With Enhanced Maturation and Reproducibility by Micro‐Topographical Cues

open access: yesAdvanced Materials, EarlyView.
Micro‐topographical cues applied through temporally controlled microscale confinement improve the reproducibility, spatial organization, and neurosensory‐associated features of pluripotent stem cell‐derived inner ear organoids. Integration with a vascularized organoid platform further enables controlled investigation of vascular‐epithelial interactions
Harshita Sharma   +15 more
wiley   +1 more source

A 3D Human Bone and Bone Marrow‐on‐a‐Chip Model for In Vitro Bone Remodeling and Immune Cell Maintenance

open access: yesAdvanced Science, EarlyView.
This study presents a human Bone (and Bone Marrow)‐on‐a‐Chip model based on native human bone scaffolds and autologous cells. Dynamic perfusion and sequential cell seeding replicate the physiological bone remodeling process in vitro, enabling the long‐term culture of functional, mature bone marrow immune subpopulations.
Nina Stelzer   +17 more
wiley   +1 more source

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