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Technetium-99m Radiopharmaceuticals
2010The name technetium was derived by the scientist Mendeleyev from the Greek word technetos, meaning “artificial.” Technetium-99m was discovered in 1937 by Perrier and Segre in a sample of naturally occurring 98Mo irradiated by neutrons and deuterons. The first generator as a source for Tc-99m was introduced in 1957 at the Brookhaven National laboratory,
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Technetium-99m nitride radiopharmaceuticals
Transition Metal Chemistry, 1997Following the introduction of an efficient method for the preparation of technetium-99m complexes containing a terminal Tc-N multiple bond, under conditions suitable for nuclear medicine applications, new radiopharmaceuticals for heart and brain imaging have been discovered.
C. BOLZATI +3 more
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Technetium-99m Pharmaceuticals
2007I.- Drug Safety.- Technetium in Medicine.- Stannous Chloride in the Preparation of 99mTc Pharmaceuticals.- Quality Assurance of Radiopharmaceuticals.- Performance and Quality Control of the 99Mo/99mTc Generator.- Preparation of Technetium 99mTc Pharmaceuticals.- Lyophilization Technique for Preparing Radiopharmaceutical Kits.- Cellular Labeling with ...
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Reproducibility of technetium-99m ethylenedicysteine clearance
European Journal of Nuclear Medicine and Molecular Imaging, 1999It has been shown that technetium-99m ethylenedicysteine ((99m)Tc-EC) clearance displays a strong correlation with orthoiodohippurate clearance and that it is possible to estimate effective renal plasma flow from (99m)Tc-EC clearance. However, in routine practice, when monitoring renal function of patients by clearance determinations it is imperative ...
L, Kabasakal +4 more
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Technetium 99m as a Scanning Agent
Radiology, 1965INTEREST has increased over the past few years in the use of technetium 99m as a radioactive tracer material for organ and tumor localization studies (1). Initially, attention was focused on this nuclide because of its favorable physical properties for biological applications (2).
P V, HARPER +4 more
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Organ Visualisation with Technetium 99m Preparations
The British Journal of Radiology, 1967Abstract Selected examples are presented in this paper to illustrate the potentialities of the use of some of the 99mTc compounds for organ visualisation. Although no attempt has been made at clinical evaluation, the additional information which can be gained by this means is both useful and impressive to those familiar with the technique.
I, Kazem, P, Gelinsky, P, Schenck
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Noncardiac uptake of technetium-99m MIBI
Seminars in Nuclear Medicine, 1994A 74-YEAR-OLD spanish-speaking Peruvian woman underwent total thyroidectomy with bilateral median neck dissection in 1977 for follicular thyroid carcinoma. This was followed by Iodine-131 (1311) ablation for remnant thyroid tissue. In 1987, a 131I whole-body scan and a computed tomography scan of the chest confirmed lung metastasis as well as ...
C W, Sutter, M J, Joshi, R C, Stadalnik
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Sub-Millimeter Technetium-99m Calibration Sources
Molecular Imaging & Biology, 2002Small animal radioscintigraphic imaging systems aim to achieve sub-millimeter resolution. At the present time, sub-millimeter calibration sources that can be placed at will within an imaged volume are not readily available. We have developed a method for producing technetium-99m (Tc-99m) sources in less than 15 minutes with readily available reagents ...
Jeffrey R, English +6 more
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Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 1998
Scintigraphic techniques are routinely used for the evaluation of the extent and severity of inflammatory bowel disease. Currently, the radiopharmaceutical of choice is 99mTc-hexamethyl propyleneamine oxime (HMPAO)-leukocytes. We studied the imaging potential of two recently developed 99mTc-labeled agents, polyethylene glycol (PEG)-coated liposomes and
Dams, E.T.M. +7 more
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Scintigraphic techniques are routinely used for the evaluation of the extent and severity of inflammatory bowel disease. Currently, the radiopharmaceutical of choice is 99mTc-hexamethyl propyleneamine oxime (HMPAO)-leukocytes. We studied the imaging potential of two recently developed 99mTc-labeled agents, polyethylene glycol (PEG)-coated liposomes and
Dams, E.T.M. +7 more
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Technetium-99m-human fibrinogen.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 1976Exogenous fibrinogen has been successfully labeled with 99mTc using a modified electrolytic method. The exact labeling mechanism has not been determined. Experimental data suggest that the labeling process of 99mTc-fibrinogen is quite similar to that of 99mTc-human serum albumin as reported earlier by Benjamin.
D W, Wong, F S, Mishkin
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