Venom peptides have shown promise in treating pain. Our study uses computer screening to identify a peptide that targets a sodium channel (NaV1.7) linked to chronic pain. We produced the peptide in the laboratory and refined its design, advancing the search for innovative pain therapies.
Gagan Sharma+8 more
wiley +1 more source
3D scanning, modelling and printing of ultra-thin nacreous shells from Jericho: a case study of small finds documentation in archaeology [PDF]
This paper springs out from a collaborative project jointly carried out by the FabLab Saperi&Co and the Museum of Near East, Egypt and Mediterranean of Sapienza University of Rome focused at producing replicas of ultra-thin archeological finds with a sub-
Fattore, Luciano+2 more
core
Causal relationships between milk quality and coagulation properties in Italian Holstein-Friesian dairy cattle [PDF]
Background: Recently, selection for milk technological traits was initiated in the Italian dairy cattle industry based on direct measures of milk coagulation properties (MCP) such as rennet coagulation time (RCT) and curd firmness 30 min after rennet ...
Cassandro, Martino+3 more
core +4 more sources
The power of microRNA regulation—insights into immunity and metabolism
MicroRNAs are emerging as crucial regulators at the intersection of metabolism and immunity. This review examines how miRNAs coordinate glucose and lipid metabolism while simultaneously modulating T‐cell development and immune responses. Moreover, it highlights how cutting‐edge artificial intelligence applications can identify miRNA biomarkers ...
Stefania Oliveto+2 more
wiley +1 more source
Impacts of real-time data collection on introductory algebra-based physics [PDF]
Including real-time data collection technology is a common practice to upgrade physics labs, and the assumption is such technology improves student learning, yet little has been done to demonstrate the effects of technology. Specific activities have been shown to be enhanced by technology, but the effects on the class as a whole has been left ...
arxiv
The Future Smart-City: An Analysis of the Effects of Global and Technological Innovation on the Evolution of Economic Systems [PDF]
In 21st century, the current economy is rapidly utilizing globalization to create a vastly different future. With the advent of new technology merging with entrepreneurs who effectively utilize that technology, the economic model is changing.
Wade, Shannon L.
core +1 more source
A Design Method to Exploit Synergies Between Fiber-Reinforce Composites and Additive Manufactured Processes [PDF]
This paper proposes a design method for devices composed of long fiber-reinforced composites (FRC) and additive manufactured (AM) parts. Both FRC and AM processes have similar application characteristics: suitable for small production volumes, additive ...
Ethan Goh+4 more
core +1 more source
Identification of novel small molecule inhibitors of ETS transcription factors
ETS transcription factors play an essential role in tumourigenesis and are indispensable for sprouting angiogenesis, a hallmark of cancer, which fuels tumour expansion and dissemination. Thus, targeting ETS transcription factor function could represent an effective, multifaceted strategy to block tumour growth. The evolutionarily conserved E‐Twenty‐Six
Shaima Abdalla+9 more
wiley +1 more source
Profiling and Evolution of Intellectual Property [PDF]
In recent years, with the rapid growth of Internet data, the number and types of scientific and technological resources are also rapidly expanding. However, the increase in the number and category of information data will also increase the cost of information acquisition. For technology-based enterprises or users, in addition to general papers, patents,
arxiv
The complex binder based on Portland cement andash-and-slag wastes from thermal power stations [PDF]
Increase in the balance of boiler and furnace fuel of the energy sector of the Republic of Belarus the proportion of own energy resources (milling peat and wood chips) places priority on resolving the issues of utilization of ash-and-slag wastes and ...
Vysotskaya, Maryia
core