Results 121 to 130 of about 4,038,530 (346)

Structural and biochemical analysis of a B12 superbinder

FEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices, Jacob J. Whittaker, Dirk J. Slotboom, Albert Guskov   +3 more
wiley   +1 more source

Structures of mycobacterial 3‐methylcrotonyl‐CoA carboxylase reveal carrier‐domain translocation between catalytic sites

FEBS Letters, EarlyView.
Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav, Bogdan I. Florea, Sebastian Geibel   +2 more
wiley   +1 more source

Assessment of the feed additive consisting of Lactiplantibacillus plantarum ATCC PTA‐6139 for all animal species for the renewal of its authorisation (Pioneer Hi‐Bred International, Inc.)

EFSA Journal
Following a request from the European Commission, EFSA was asked to deliver a scientific opinion on the assessment of the application for renewal of Lactiplantibacillus plantarum (formerly Lactobacillus plantarum) ATCC PTA‐6139 as a technological ...
EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP), Vasileios Bampidis, Giovanna Azimonti, Maria de Lourdes Bastos, Henrik Christensen, Mojca Durjava, Birgit Dusemund, Maryline Kouba, Marta López‐Alonso, Secundino López Puente, Francesca Marcon, Baltasar Mayo, Alena Pechová, Mariana Petkova, Fernando Ramos, Roberto Edoardo Villa, Ruud Woutersen, Paul Brantom, Montserrat Anguita, Nicole Bozzi Cionci, Rosella Brozzi, Jaume Galobart, Matteo L. Innocenti, Joana Revez   +23 more
doaj   +1 more source

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

FEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge, Vivian Pogenberg, Alexander Baumgart, Bente Siebels, Hartmut Schlüter, Michael Hecht‐Bucher, Aymelt Itzen   +6 more
wiley   +1 more source

Safety evaluation of certain contaminants in food: prepared by the eighty-third meeting of the Joint FAO/WHO Expert Committee on Food Additives (JECFA)

, 2018
983 p.This volume presents safety evaluations of selected food contaminants considered by the Joint FAO/WHO Expert Committee on Food Additives (JECFA) at its eighty-third meeting, held in Rome in November 2016.
World Health Organization, Food and Agriculture Organization of the United Nations   +1 more
core  

ADDITIVES IN CANDIES

, 2021
Prehrambeni aditivi su tvari poznatog sastava, koje nisu hrana, nego se dodaju namirnicama prilikom proizvodnje, transporta, oblikovanja, prerade i čuvanja hrane.
Markioli, Barbara
core  

Prospecting the protein design landscape

FEBS Letters, EarlyView.
This review outlines the current state of various protein design approaches. We discuss the current possibilities enabled by recently released tools, highlight future avenues to pursue in protein design, and underscore the crucial role of key databases and resources for successful protein design workflows.
Jakob R. Riccabona, Katharina T. Stonig, Jens Meiler, Clara T. Schoeder, Monica L. Fernández‐Quintero   +4 more
wiley   +1 more source

Prospective trends for the use of probiotics for the creation of polyfunctional feed additives [PDF]

, 2018
The article gives an overview of promising trends for the use of probiotics for the creation of feed additives, on the basis of which it was concluded that it is expedient to create feed additives containing a complex of probiotics and prebiotics that ...
A. D. Achmiz, A. S. Borodikhin, A. N. Matvienko, R. V. Kazaryan, M. V. Lukyanenko   +4 more
core  

A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma

FEBS Letters, EarlyView.
Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos, Antonia Petropoulou, Alexandra Anastogianni, Angelina Bania, Vassilis Stamatakis, Argyris Alexiou, Chi‐Ping Day, Glenn Merlino, Katerina Grafanaki, Constantinos Stathopoulos   +9 more
wiley   +1 more source

ADDITIVES FOR COLD ASPHALT-CONCRETE MADE FROM EMULSION-MINERAL MIXES [PDF]

, 2015
The article considers the additives use for cold asphalt emulsion mixes. Urgency of the issue consists in the necessity of usage justification and regulation of additive for cold mixes properties adjustment.
P. V. Vavilov, S. E. Kravchenko
core