Results 101 to 110 of about 107,618 (238)
Molecular Oncology, EarlyView.Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee +8 more
wiley +1 more source
Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source
Chemical Engineering Journal AdvancesThe electrochemical reduction of CO2 (eCO2R) from carbon capture solutions, such as (bi)carbonate, offers a promising pathway for energy-efficient carbon recycling compared to traditional gas-phase approaches.
Ramato Ashu Tufa +8 more
doaj +1 more source
The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity
Molecular Oncology, EarlyView.Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli +7 more
wiley +1 more source
Targeting p38α in cancer: challenges, opportunities, and emerging strategies
Molecular Oncology, EarlyView.p38α normally regulates cellular stress responses and homeostasis and suppresses malignant transformation. In cancer, however, p38α is co‐opted to drive context‐dependent proliferation and dissemination. p38α also supports key functions in cells of the tumor microenvironment, including fibroblasts, myeloid cells, and T lymphocytes.
Angel R. Nebreda
wiley +1 more source
A proposal for measuring the innovation performance: an application in spanish innovative firms
Management Letters/Cuadernos de Gestión, 2013 This paper supplies a measure of the degree of firms innovation performance. This indicator summarizes the impact of technological innovation activities on products, processes and sustainability of the firms. The data set used in this study was drawn up
María A. Quintás +2 more
doaj
Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin
Molecular Oncology, EarlyView.Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon +4 more
wiley +1 more source
Evolution of Particle Characterization: Past, Present, and Future
KONA Powder and Particle JournalParticle characterization underpins a wide range of fields, including mineral processing, materials science, nanotechnology, pharmaceuticals, food processing, agriculture, and environmental applications, by providing essential information on particle ...
Vasanthakumar Balasubramanian +1 more
doaj +1 more source
Structural and Technological Characterization of Tropical Smallholder Farms of Dual-Purpose Cattle in Mexico. [PDF]
Animals (Basel), 2020 Rangel J +7 more
europepmc +1 more source