Results 61 to 70 of about 668,692 (311)
FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source
International Journal of Communication, 2012 This is Part I of a two-part article that reviews methodological and statistical challenges involved in the estimation of humanity’s technological capacity to communicate, store, and compute information.
Martin Hilbert, Priscila López
doaj
Retail Central Bank Digital Currency Design Choices: Guide for Policymakers
IEEE AccessCentral bank digital currencies (CBDCs), particularly retail CBDCs intended for daily public transactions, have garnered attention globally. Benefits of CBDC implementation heavily depend on its design, which, if not executed well, can lead to ...
Anastasia Tsareva, Mikhail Komarov
doaj +1 more source
Natural endowments, production technologies, and the quality of wines in Bordeaux. Is it possible to produce wine on paved roads? [PDF]
We study whether quality assessments made by wine experts and by consumers (based on prices obtained at auction between 1980 and 1992), can be explained by variables describing endowments (land characteristics, exposures of vineyards) and technologies ...
Gergaud, Olivier, Ginsburgh, Victor
core +1 more source
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
From design to management: a benchmarking process for the energy efficiency of buildings
Techne, 2013 Environmental quality and energy efficiency are strategic objectives which can highlight the ‘effectiveness’ of design and technological choices, as well as the impact of management strategies and user behaviour. Studies show it is possible to narrow the
Judit Kimpian +3 more
doaj +1 more source
Firm Location and the Creation and Utilization of Human Capital [PDF]
This paper presents a theory of location choice that draws on insights from the incomplete contracts and investment flexibility (real option) literatures.
Adolfo de Motta +2 more
core
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
The process for technology transfer in Baltimore [PDF]
Ingredients essential for a successful decision process relative to proper technological choices for a large city were determined during four years of experience in the NASA/Baltimore Applications Project.
Golden, T. S.
core +1 more source
Architectural choices for the Columbia 0.8 Teraflops machine
, 1994 We discuss the hardware design choices made in our 16K-node 0.8 Teraflops supercomputer project, a machine architecture optimized for full QCD calculations.
Airiau +4 more
core +1 more source