Results 81 to 90 of about 60,601 (309)

The Optimal Control of Technology Choices [PDF]

open access: yes
We may distinguish between two concepts of technology: a theoretical level of technology (that is, a technology possibilities frontier) and a level of technology in practice (that is, ready to use in production technology).
Orlando Gomes
core  

Older people leisure places, and wellbeing: older scuba divers, hill walkers & sea swimmers in Ireland

open access: yes, 2022
Humans have a longstanding desire to live longer and healthier lives (Ekerdt et al., 2017). Medical advancements, immunisation and knowledge regarding lifestyle choices have contributed to rising life expectancy (WHO, 2011). While adding years to life is
Tierney, Joe
core  

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

open access: yesFEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens   +8 more
wiley   +1 more source

AN APPROACH TO THE MEASUREMENT OF TECHNOLOGICAL CHANGE BASED ON THE INTENSITY OF INNOVATION [PDF]

open access: yes
The economics of innovation presents a lot of taxonomies of innovation. This research introduces the scale of innovative intensity (SIIN) based on a meta-taxonomy that subsume other, less comprehensive taxonomy.
Mario Coccia
core  

Emerging Insights from an Evaluative Study: exploring the impact of active Learning on academic practice in blended and online learning [PDF]

open access: yes, 2022
This reflection is based on the initial key finding from a research study exploring the impact of Active Learning on Academic Practice in Blended and Online Learning. The findings are based on a review of literature in the area of active learning and
O'Toole, Sarah
core  

Mixed‐class J‐domain protein scaffolds promote expanded aggregate handling and multivalent Hsp70 engagement during functional disaggregase assembly

open access: yesFEBS Letters, EarlyView.
Protein aggregates threaten proteostasis and cell health. In human cells, Hsp70–J‐domain protein‐based disaggregases remove aggregates, but how they assemble remains unclear. Our biochemical findings show that DNAJA2‐ and DNAJB1‐containing disaggregase scaffolds enhance luciferase aggregate targeting, and that Hsp70 recruitment by both J‐domain ...
Anna Szlachcic, Nadinath B. Nillegoda
wiley   +1 more source

An Investigation of Environmental Factors that Influence Student's Decision to Study Information Technology: A Qualitative Approach

open access: yesJournal of Information Systems and Informatics
Selecting a career path is crucial for students' future success and job market readiness. This study underscores the need to align education with career goals for an easier transition from school to work.
Xolisa Philip Piyose   +2 more
doaj   +1 more source

Integration of sustainability requirements in architectural design

open access: yesTechne, 2019
The paper explores the integration of technological and environmental requirements in the architectural design, as these are recently defined by the European and national policy pieces.
Valentina Marino, Francesca Thiébat
doaj   +1 more source

Induced Technological Change under Technology Competition [PDF]

open access: yes
We develop a partial one-sector model with capital, natural resources, and labor as production factors, and endogenous technological change through research. Production exhibits increasing returns to scale.
Reyer Gerlagh
core  

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

open access: yesMolecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce   +11 more
wiley   +1 more source

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