Results 41 to 50 of about 1,247,283 (309)

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Technological innovation and profit

Journal of Open Innovation: Technology, Market and Complexity
This study examines the effect of technological innovation on economic performance. Solow’s growth accounting measures the contribution of productivity to economic growth, but the active role of technological change in attaining economic growth is ...
Sanghoon Lee
doaj   +1 more source

SCIENTIFIC AND TECHNOLOGICAL INNOVATION [PDF]

Annals: Series on engineering sciences (Academy of Romanian Scientists), 2011
Today, science and, accordingly, scientific research is widely recognized as the main driving force of production and source of innovation and technology transfer.
Gabriel I. NASTASE, Dragos Ionut G. NASTASE, Cristina ILIESCU   +2 more
doaj  

Empirical study of national technological innovation capability in Africa

South African Journal of Economic and Management Sciences, 2012
This paper performs an analysis of the technological innovation capability in 30 African countries. Based on the literature about national innovation capability and economy of technological change, an empirical study using clusters’ analysis technique ...
Mónica García-Ochoa Mayor, María Luisa Blázquez de la Hera, Enrique de Diego Ruiz   +2 more
doaj   +1 more source

Technological Innovation

Journal of Global Information Management, 2018
The Mobile Internet Information Technology (MIIT) has been widely accepted as one of the most promising technologies in the next decades, having various applications and different value positions. However, few published studies explore and examine the effects of MIIT on community management.
Su, Wan, Xu, Xiaobo, Li, Yangchun, Martinez-Lopez, Francisco J., Li, Ling   +4 more
openaire   +2 more sources

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Influencing Factors Analysis in Railway Engineering Technological Innovation under Complex and Difficult Areas: A System Dynamics Approach

Mathematics
The geological complexity, environmental sensitivity, and ecological fragility inherent in complex and difficult areas (CDAs) present new opportunities and challenges for technological innovation in railway engineering development in China.
Chaoxun Cai, Shiyu Tian, Yuefeng Shi, Yongjun Chen, Xiaojian Li   +4 more
doaj   +1 more source