Results 51 to 60 of about 303,086 (310)

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

FEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas, Brigitta Maruzs, Zsófia E. Kálmán, Tomas Klumpler, Gyula Batta, Bálint Péterfia, Zoltán Gáspári   +6 more
wiley   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Influencing Factors Analysis in Railway Engineering Technological Innovation under Complex and Difficult Areas: A System Dynamics Approach

Mathematics
The geological complexity, environmental sensitivity, and ecological fragility inherent in complex and difficult areas (CDAs) present new opportunities and challenges for technological innovation in railway engineering development in China.
Chaoxun Cai, Shiyu Tian, Yuefeng Shi, Yongjun Chen, Xiaojian Li   +4 more
doaj   +1 more source

Innovation in service industry: the role of consultants

Journal of Innovation Management, 2018
Much of the existing literature on innovation intermediaries is focused on manufacturing, and limited scientific knowledge has been developed about the role of intermediaries in services.
Manuela Dias Rezende Pinto, Irina Saur-Amaral, Carlos Melo Brito   +2 more
doaj   +1 more source

The impact of the economic crisis on innovation: evidence from Europe [PDF]

, 2012
Economic crises cause companies to reduce their investment, including investment in innovation where returns are uncertain and long-term. This has been confirmed by the 2008 financial crisis, which has substantially reduced the willingness of firms to ...
Frenz, Marion, Filippetti, Andrea, Archibugi, Daniele   +2 more
core   +1 more source

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Innovations in Microfinance technologies

The Journal of Community Informatics, 2008
An experience to implement PDA technology has been done in Mali, in 2003-2005, to modernize banking operations for a microfinance institution (MFI). This project gave the occasion to experiment the mobile technology, but also the possibility for the poor population to have access to financial services, even if they are far from a large city (rural ...
openaire   +2 more sources

Innovation and transportation's technologies [PDF]

Journal of Advanced Transportation, 2000
AbstractI critique the innovation processes that yield transportation's technologies, and to aid my analysis I look back to take advantage of the accumulation of experiences and insights marked by the millennium.I identify supply, transport, and user systems.
openaire   +3 more sources

District heating in the UK:A Technological Innovation Systems analysis [PDF]

, 2012
District heating infrastructure could contribute to the UK's energy policy goals of decarbonisation, renewable energy deployment, tackling fuel poverty and ensuring energy security.
Hawkey, David
core   +1 more source