Results 101 to 110 of about 245,064 (314)
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Basic and Applied Research AI Requirements ISO of the Battlespace to Ensure Decision Superiority
NPS NRP Executive SummaryWith the problem of a chasm between available mature Artificial Intelligence/Machine Learning (AI/ML) data strategy and novel frameworks on one hand, and lagging Research, Development, Testing, and Evaluation (RDT&E) requirements
Godin, Arkady
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Diversitas JournalThis study evaluated the Bachelor of Physical Education (BPED) program at Rizal Technological University by applying the Engagement Theory Program Quality (ETPQ) framework.
Jeric Quibral
doaj +1 more source
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
Opportunities for participation in PFUR scientific and technical programs of “Eureka”
RUDN Journal of Engineering Research, 2013 The article presents information on the projects of the European scientific and technical program Eureka. The structure of the program, the authorities within the structure, subject area, and the activities of the program.
N S Kirabaev +2 more
doaj
Molecular Oncology, EarlyView.A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel +12 more
wiley +1 more source
CGIAR Research Program on Policies, Institutions, and Markets: Priorities for 2019–2021
The CGIAR Research Program on Policies, Institutions, and Markets (PIM) works with research and implementation partners in Africa, Asia, and Latin America to generate evidence, develop capacity, and support policies that help poor people, both men and ...
CGIAR Research Program on Policies, Institutions, and Markets
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Technological discontinuities, outsiders and social capital: a case study from Formula 1
, 2012 Purpose – The purpose of this paper is to examine how and why outsiders, rather than incumbents, are able to take advantage of technological discontinuities.
Smith, DJ
core +1 more source
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
Validation of Power Generation Prototypes in the Arctic Environment
The Arctic environment is changing and has become significantly different from what was studied in the 1970’s and 1980’s. These changing environmental conditions in the Arctic create new complexities for Antisubmarine Warfare (ASW), calling for a change ...
Joseph, John E., Reeder, D. Benjamin
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