Results 81 to 90 of about 245,064 (314)

Mushroom stem-based diets elicit region-specific shifts in rainbow trout gut microbiota

Scientific Reports
The intestinal microbiota of fish plays a crucial role in host condition and health, exhibiting region-specific functions influenced by dietary components.
Carl John Saromines, Samira Reinoso, Alberto Ruiz, Silvia Torrecillas, Maria Luisa Tello Martín, Margarita Pérez Clavijo, Enric Gisbert   +6 more
doaj   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

Functions of innovation systems as a framework to understand sustainable technological change: empirical evidence for earlier claims [PDF]

Understanding the emergence of innovation systems is recently put central in research analysing the process of technological change. Especially the key-activities that are important for the build up of an innovation system receive much attention.
Simona O. Negro, Marko P. Hekkert
core  

Capability Analysis of Ship-Based UAS for Polar Operations

, 2020
NPS NRP Executive SummaryWith the current emphasis on Arctic operations, this research investigates the operational capabilities of unmanned aerial systems (UAS) used for search and rescue (SAR) and intelligence, surveillance, and reconnaissance (ISR) in
Hale, Britta
core  

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

ARE VOCATIONAL SCHOOL STUDENTS READY TO FACE WORKFORCE DISRUPTION IN THE CONSTRUCTION FIELD?

Jurnal Pensil
The purpose of this research is to 1) Describe the digital literacy understanding of vocational high school students in the Construction and Property Engineering program.
Anas Arfandi, Akshari Tahir Lopa, Hasbi
doaj   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Exploring the relationship between scientist human capital and firm performance: The case of biomedical academic entrepreneurs in the SBIR Program. [PDF]

Do academic scientists bring valuable human capital to the companies they found or join? If so, what are the particular skills that compose their human capital and how are these skills related to firm performance?
Toole, A, Czarnitzki, Dirk
core   +2 more sources

Activating Technology for Connected Health in Cancer: Protocol for a Research and Training Program

JMIR Research Protocols, 2018
As cancer survival rates increase, the challenge of ensuring that cancer survivors reclaim their quality of life (QoL) becomes more important. This paper outlines the research element of a research and training program that is designed to do just that.Bridging sectors, disciplines, and geographies, it brings together eight PhD projects and students ...
Nicola Mountford, Enrique Dorronzoro Zubiete, Threase Kessie, Begonya Garcia-Zapirain, Roberto Nuño-Solinís, David Coyle, Kristin B Munksgaard, Luis Fernandez-Luque, Octavio Rivera Romero, Matilde Mora Fernandez, Pedro Valero Jimenez, Ailish Daly, Ruth Whelan, Brian Caulfield   +13 more
openaire   +7 more sources