Results 131 to 140 of about 245,064 (314)
PARP inhibitors induce a senescence phenotype in non‐small cell lung carcinoma cell lines
FEBS Open Bio, EarlyView.Talazoparib is the most potent inducer of senescence among different PARP1 inhibitors in human NSCLC cells. In the absence of PARP, no senescence phenotype was observed, demonstrating that PARP1 is necessary for the induction of senescence by this inhibitor.
Camille Huart +7 more
wiley +1 more source
, 2011 This report, part one of two, contains a description of the study methodology from Findings from the Targeted Research Grant: Assessing the Impact and Sustainability of the Advanced Technological Education Program (NSF Grant Number 0832874).
Welch, Wayne
core
FEBS Open Bio, EarlyView.Erythropoietin administration suppresses hepatic soluble epoxide hydrolase (sEH) expression, leading to increased CYP‐derived epoxides. This is associated with a shift in hepatic macrophage polarization characterized by reduced M1 markers and increased M2 markers, along with reduced hepatic inflammation, suppressed hepatic lipogenesis, and attenuated ...
Takeshi Goda +12 more
wiley +1 more source
FEBS Open Bio, EarlyView.Amino acids sequence of two different proteins with the same sequence (chameleon sequence—black boxes) represent in 3D structure of the proteins different secondary structures: HHHH—helical and BBB—Beta‐structural. The chains folded in water environment adopt different III‐order structures in which the chameleon fragments appear to adopt similar status
Irena Roterman +4 more
wiley +1 more source
Impact analysis of technological public services supplied to local firms: a methodology [PDF]
The aim of this work is to present a methodology useful to verify the impact of public interventions directed to support the technological innovation in local groups of SMEs.
Serena Novero
core
Future Fleet Wargames - Post Wargame Experimentation and Analysis [PDF]
, 2018 NPS NRP Executive SummaryProject Summary: This project's goal was to establish an ability for the Navy's N9 Warfare Systems Directorate to develop insights regarding the impact of planned and scheduled future naval capabilities on the operational success
Sanchez, Susan M. +8 more
core
Development of human monoclonal antibodies against TARM1 by yeast display
FEBS Open Bio, EarlyView.Human monoclonal antibodies against TARM1 are generated by yeast display‐guided selection. These antibodies bind to soluble and cell‐surface forms of TARM1. Also, these antibodies exhibit agonistic activity in the NFAT‐GFP reporter assay, indicating that TARM1 signaling can be functionally modulated by antibodies and suggesting TARM1 as a potential ...
Rikio Yabe +5 more
wiley +1 more source
IPRs, Technological Development, and Economic Development
In the year 2000 some $142 billion in royalties were paid internationally by users of a specific piece of knowledge that were protected under Intellectual Property Right law (IPR) to those parties that owned these rights.
Dolfsma, W.A.
core
Generation of Human Views with Monterey Phoenix [PDF]
, 2016 This research advances model-based systems engineering approaches and tools for representing human behaviors in terms of decision-making processes and choices, and integrating human models with technological system models to predict and purge unintended ...
Giammarco, Kristin, Moulds, Tom
core
FEBS Open Bio, EarlyView.Matrix metalloproteinase‐9 (MMP9) drives ovarian cancer progression. Using MMP9‐null cells (M9‐KO) created from ovarian cancer cells, we found MMP9 loss did not block Epidermal Growth Factor (EGF)‐driven E‐cadherin dissolution or EMT but delayed and reduced EGF‐driven membrane protrusions. Transient MMP9 re‐expression drove membrane protrusion.
Claire Strauel +8 more
wiley +1 more source