Results 31 to 40 of about 2,155,838 (234)
Organoids in pediatric cancer research
FEBS Letters, EarlyView.Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley +1 more source
Evolution of Technology and Technology Governance [PDF]
Journal of Open Innovation: Technology, Market, and Complexity, 2020 This study is based on the concept of Kondratiev’s technological waves as an analytical instrument for examining the processes of technological evolution. It aims at setting feasible indicators for this evolutionary development in order to provide a regulatory instrument for policy makers.
Almgren, Richard, Skobelev, Dmitry
openaire +3 more sources
FEBS Letters, EarlyView.Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho +3 more
wiley +1 more source
Smart Cities: Necessity and Development Strategies
Informaciâ i Innovacii, 2020 In the twenty-first century different countries and cities are increasingly seeking to introduce quality improvements in their livelihoods, generate for its residents an environment that is called “smart city” on the basis of high technologies.
L. V. Shkvarya, A. S. Semenov
doaj +1 more source
Mechanism of Managing Digital Ecosystem Development
Вестник Российского экономического университета имени Г. В. Плеханова, 2022 When economic landscape is changing both ecosystems development and their effective management became very important. The author shows goals, objectives and principles necessary for effective functioning of the mechanism of managing ecosystem development
O. E. Kalenov
doaj +1 more source
Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?
FEBS Letters, EarlyView.This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes +3 more
wiley +1 more source
Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
FEBS Letters, EarlyView.Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source
FEBS Letters, EarlyView.The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li +2 more
wiley +1 more source
FEBS Letters, EarlyView.We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee +3 more
wiley +1 more source
IMPROVEMENT OF FINANCIAL SUPPORT OF RAISING PRODUCT QUALITY WITH THE HELP OF SMART MANAGEMENT INFORMATION SYSTEMS [PDF]
Proceedings on Engineering SciencesWe analysed the directions for improving financing for the growth of quality in the conditions of smart production and revealed the advantages and features of their realisation in developing and developed countries.
Sultonali U. Mekhmonov +4 more
doaj +1 more source