Results 51 to 60 of about 2,275,255 (233)

Humanización del aprendizaje en la era de la información: una arista andragógica / Humanization of the learning at the information age: an edge from the andragogy

Actualidades Investigativas en Educación, 2013
Actualmente la sociedad atraviesa una etapa muy interesante, incidida por las tecnologías de la información y la comunicación (TIC), nuevos descubrimientos de la neurociencia que proponen formas distintas de analizar los estilos de aprendizaje, además ...
José Laurian Ramírez Díaz
doaj   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Methods and technologies of disposal of poly-chloride biphenyls in transformer oils

Вестник Научно-исследовательского института железнодорожного транспорта, 2016
A review of the main methods of disposal of waste containing polychlorinated biphenyls (PCBs) is presented. It is shown that a reliable, environmentally friendly and efficient process does not exist, and, apparently, it is impossible to create a ...
V. M. Bel’Kov
doaj   +1 more source

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

Modern possibilities of treating brain tumors: intraoperative technologies in neurooncology

Клиническая практика
The fundamental principle of neurooncology is the maximal removal of the tumor, simultaneously minimizing the effects on the healthy brain structures.
Arthur I. Nafikov, Radmir I. Minnigaleev, Elina R. Yarullina, Eminat M. Magomedova, Karina G. Soboleva, Maksim M. Sobolev, Oishakhon R. Egamova, Yulia A. Kirillova, Arut A. Arutyunyan, Fatimat A. Tokhova, Nurlana A. Abbasova, Khanipat Kh. Saadueva, Ilshat F. Yarmeev   +12 more
doaj   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Advances in Recycling Technologies of Critical Metals and Resources from Cathodes and Anodes in Spent Lithium-Ion Batteries

Separations
With the rapid economic development and the continuous growth in the demand for new energy vehicles and energy storage systems, a significant number of waste lithium-ion batteries are expected to enter the market in the future.
Shuwen Wang, Yanrong Lai, Jingran Yang, Jiaxue Zhao, Yushan Zhang, Miaoling Chen, Jinfeng Tang, Junhua Xu, Minhua Su   +8 more
doaj   +1 more source