Results 61 to 70 of about 7,527,785 (272)

The newfound relationship between extrachromosomal DNAs and excised signal circles

open access: yesFEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

Plasmonics for emerging quantum technologies [PDF]

open access: yes, 2016
Expanding the frontiers of information processing technologies and, in particular, computing with ever increasing speed and capacity has long been recognized an important societal challenge, calling for the development of the next generation of quantum ...
Bozhevolnyi, Sergey I.   +1 more
core   +4 more sources

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

open access: yesFEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka   +11 more
wiley   +1 more source

Humanización del aprendizaje en la era de la información: una arista andragógica / Humanization of the learning at the information age: an edge from the andragogy

open access: yesActualidades Investigativas en Educación, 2013
Actualmente la sociedad atraviesa una etapa muy interesante, incidida por las tecnologías de la información y la comunicación (TIC), nuevos descubrimientos de la neurociencia que proponen formas distintas de analizar los estilos de aprendizaje, además ...
José Laurian Ramírez Díaz
doaj   +1 more source

Technologies for the Disabled [PDF]

open access: yes, 2017
Nowadays computers have taken the dominant role in our society.Most jobs now require access to computers and the Internet. But what happens if a person is blind, deaf or physically disabled?
Grechikhina, Julia   +2 more
core  

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

open access: yesFEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva   +10 more
wiley   +1 more source

Methods and technologies of disposal of poly-chloride biphenyls in transformer oils

open access: yesВестник Научно-исследовательского института железнодорожного транспорта, 2016
A review of the main methods of disposal of waste containing polychlorinated biphenyls (PCBs) is presented. It is shown that a reliable, environmentally friendly and efficient process does not exist, and, apparently, it is impossible to create a ...
V. M. Bel’Kov
doaj   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

Structural biology of ferritin nanocages

open access: yesFEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

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