Results 231 to 240 of about 9,066,262 (300)

Microglial Deubiquitinase OTUD7B Stabilizes STAT3 to Promote Neuroinflammation and Cognitive Decline in Alzheimer's Disease

Advanced Science, EarlyView.
. ABSTRACT Neuroinflammation driven by microglial activation is a defining feature of Alzheimer's disease (AD), yet the molecular mechanisms sustaining this proinflammatory state remain unclear. Here, we identify the deubiquitinase OTUD7B as a critical regulator of microglial activation and AD pathology.
Luyao Li, Hao Tang, Qin Yu, Yuyang Zhang, Binglu Shi, Ying Kong, Leiyu Xu, Jingjing Shao, Chenghong Hu, Lingyu She, Zhe Wang, Haiyi Chen, Aleksandr V. Samorodov, Gang Cao, Xia Zhao, Yi Wang   +15 more
wiley   +1 more source

Retraction: Designing a novel visible-light-driven heterostructure Ni-ZnO/S-g-C₃N₄ photocatalyst for coloured pollutant degradation. [PDF]

RSC Adv
Bahadur A, Iqbal S, Alsaab HO, Awwad NS, Ibrahium HA.   +4 more
europepmc   +1 more source

VDAC1 Upregulation Induces Hyperexcitability of Nociceptive Sensory Neurons Via Enhanced Mitochondrial Atp Efflux in Neuropathic Pain

Advanced Science, EarlyView.
The mechanism diagram of VDAC1 mediating neuronal excitability and neuropathic pain. Briefly, VDAC1 is expressed in DRG neurons and is upregulated following CCI‐induced neuropathic pain. This upregulation enhances ATP transport from mitochondria to the cytoplasm in sensory neurons, leading to increased neuronal excitability and pain behavior.
Fengrun Sun, Ning Yu, Liang Yu, Xiaofen Tian, Yujia Ma, Yikuan Xie, Tao Wang, Chao Ma   +7 more
wiley   +1 more source

Integrated Evidence Generation Planning: Why Medical Affairs is a Critical Partner. [PDF]

Pharmaceut Med
Fujii R, Nouri M, Khan M, Fleisinger L, Pugh J, Male G, Panayi A.   +6 more
europepmc   +1 more source

TOLLIP Inhibits Psoriasis Progression via Suppressing PKM2‐Mediated Glycolysis in Keratinocytes

Advanced Science, EarlyView.
In this study, we identify TOLLIP as a critical regulator of psoriasis pathogenesis through its modulation of glycolytic metabolism. Our findings establish the TOLLIP‐PKM2‐glycolysis axis as a key mechanism linking metabolic reprogramming to psoriasis pathogenesis, and propose TOLLIP as a promising therapeutic target.
Xiuhuan Jiang, Guoying Miao, Na Shen, Qingxia Han, Xiaoru Han, Zichang Qiao, Kexin Feng, Zhuo Tan, Yaguang Wang, Xiuhua Liu, Chen Wu, Zhenzhen Yan   +11 more
wiley   +1 more source

"Biodegradable caterpillar inspired soft robotic systems for targeted therapeutic delivery with intelligent <i>in vivo</i> navigation". [PDF]

RSC Adv
Pothal P, Sharma R, Verma R, Kumar D, Mundlia P, Dhiman V, Bhadada SK, Goel H, Ranawat P, Barnwal RP, Singh G.   +10 more
europepmc   +1 more source

Spectrum meets sustainability: green-validated novel simultaneous assays of antimicrobial fixed dose combination. [PDF]

BMC Chem
Guirguis KM, Kamal MF, Al-Dokhmaisy EH, Daabees HG, Kaddah MMY.   +4 more
europepmc   +1 more source

From innovation network to public health benefit: evolutionary characteristics and optimization of the biomedical industry innovation network in the Beijing-Tianjin-Hebei region. [PDF]

Front Public Health
Xie X, Xiang M, Tan Q.
europepmc   +1 more source

An HBT-based "off-on" fluorescent probe for direct detection of methyl parathion in environmental water and Chinese medicine samples. [PDF]

RSC Adv
Geng Y, Zhang W, Li LT, Tian Y, Zhai BQ, Bi WZ, Wang YG.   +6 more
europepmc   +1 more source