Results 241 to 250 of about 424,358 (303)

A negative survival pressure selection system enables GPCR antagonist screening. [PDF]

Cell Discov
Xu T, Sun Q, Zhang S, Liu T, Sun X, Wang X, Lin B, Liu Z, Wang J, He G, Liu X.   +10 more
europepmc   +1 more source

Mitochondria and Neuromast Tagging With Fluorescent Gallium‐Triapine Analogues: In Cellulo MP FLIM and Zebrafish Live Imaging

Advanced Science, EarlyView.
Fluorescent BODIPY‐conjugated thiosemicarbazone ligands and their Ga(III), In(III), and Fe(III) complexes, inspired by Triapine, are developed as theranostic agents. Multiphoton FLIM and confocal microscopy in cancer cells and zebrafish reveal real‐time uptake, mitochondrial localisation, and whilst spectroscopic assays indicated preserved complex ...
Megan J. Green, Michael W. Jones, Merissa Saleem, Haobo Ge, Melita Tvardauskaite, Julia Dudzic, Fernando Cortezon‐Tamarit, Rory L. Arrowsmith, Charareh Pourzand, Gabriele Kociock‐Kohn, Nicholas H. Rees, Jonathan R. Dilworth, Stephen Faulkner, Stanley W. Botchway, David Gurevich, Sofia I. Pascu   +15 more
wiley   +1 more source

Protection of Hygroscopic Pharmaceutical and Nutraceutical Active Ingredients via Film Coating Technologies: A Review. [PDF]

Drug Des Devel Ther
Pitriani P, Mulyani AT, Wardhana YW, Chaerunisaa AY.   +3 more
europepmc   +1 more source

Mitigating Cancer Therapy–Related Cognitive Impairment by Targeted Activation of Undruggable Phosphatase

Advanced Science, EarlyView.
An RVG‑engineered exosomal saRNA delivery system (RVG‑EVs‑saPtpro) effectively targets and activates hippocampal PTPRO, functioning as a “molecular brake” to alleviate cancer therapy‑related cognitive impairment (CTRCI) by enhancing neuronal survival, neurogenesis, and synaptic plasticity.
Zhimeng Yao, Yuhua Meng, Huanyi Li, Yinhui Jiang, Xiaona Lin, Mengyuan Hu, Qing Liu, Xiaofu Qiu, Hongzheng Ren, Yunlong Pan, Bin Pan, Zexiong Guo, Shuyao Zhang, Dianzheng Zhang, Li Yang, Shegan Gao, Weijing Deng, Jianfan Chen, Hao Zhang   +18 more
wiley   +1 more source

Strategic applications of heterocyclic compounds in pharmaceutical innovation: a business perspective. [PDF]

Front Chem
Dong Y, Dai J, Zou Y, Rajalakshmi K, Kiruthiga N, Balaji P, Zhu D.   +6 more
europepmc   +1 more source

Perception of artificial intelligence and machine learning applications in the Nigerian healthcare sector: A cross-sectional study. [PDF]

PLOS Glob Public Health
Adigwe OP, Onavbavba G.
europepmc   +1 more source

Increasing access to CAR-T therapy: a case study of an academic hospital's alternative innovation model. [PDF]

Orphanet J Rare Dis
Ruiz AA, Shinabargar E, Slovenski I, Large K, Vieira M, Moon S.   +5 more
europepmc   +1 more source

Integrating multivariate analysis and Air Pollution Tolerance Index (APTI) to evaluate four ornamental plants for sustainable indoor air phytoremediation. [PDF]

Sci Rep
Elhadad SM, Ea S, Saleh IH, Omar MY.
europepmc   +1 more source

Quantifying public and private investment in biopharmaceutical R&D: a study of seven middle- and high-income countries. [PDF]

J Pharm Policy Pract
Fowler A, Tantri A, Spencer J, Grieve K, Pendharkar T, Da Silva Duarte Lepez S, Wilsdon T.   +6 more
europepmc   +1 more source