Results 61 to 70 of about 1,225,508 (272)

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Harnessing Technology: new modes of technology-enhanced learning: opportunities and challenges [PDF]

, 2009
A report commissioned by Becta to explore the potential impact on education, staff and learners of new modes of technology enhanced learning, envisaged as becoming available in subsequent years.
Balmer, Kim, Chowcat, Ian, Crook, Charles, Jones, Ian, Kay, David, Sharples, Mike, Stokes, Eleanor   +6 more
core  

Rethinking plastic waste: innovations in enzymatic breakdown of oil‐based polyesters and bioplastics

FEBS Open Bio, EarlyView.
Plastic pollution remains a critical environmental challenge, and current mechanical and chemical recycling methods are insufficient to achieve a fully circular economy. This review highlights recent breakthroughs in the enzymatic depolymerization of both oil‐derived polyesters and bioplastics, including high‐throughput protein engineering, de novo ...
Elena Rosini, Nicolò Antonelli, Gianluca Molla   +2 more
wiley   +1 more source

A virtual practice community for student learning and staff development in health and social work inter-professional education. Mini-project evaluation report. [PDF]

, 2008
Interprofessional education (IPE) has been widely advocated and developed as a means to encourage effective collaboration in order to improve public sector services.
Hutchings, Maggie, Quinney, Anne, Scammell, Janet   +2 more
core  

Homologous expression and purification of human HAX‐1 for structural studies

FEBS Open Bio, EarlyView.
This research protocol provides detailed instructions for cloning, expressing, and purifying large quantities of the intrinsically disordered human HAX‐1 protein, N‐terminally fused to a cleavable superfolder GFP, from mammalian cells. HAX‐1 is predicted to undergo posttranslational modifications and to interact with membranes, various cellular ...
Mariana Grieben
wiley   +1 more source

Learning design approaches for personalised and non-personalised e-learling systems [PDF]

, 2011
Recognizing the powerful role that technology plays in the lives of people, researchers are increasingly focusing on the most effective uses of technology to support learning and teaching.
Bacon, Liz, Cemal Nat, Muesser, Dastbaz, Mohammad, Walker, Simon   +3 more
core  

Overview of molecular signatures of senescence and associated resources: pros and cons

FEBS Open Bio, EarlyView.
Cells can enter a stress response state termed cellular senescence that is involved in various diseases and aging. Detecting these cells is challenging due to the lack of universal biomarkers. This review presents the current state of senescence identification, from biomarkers to molecular signatures, compares tools and approaches, and highlights ...
Orestis A. Ntintas, Sylvia Vagena, Pavlos Pantelis, Giorgos Theocharous, Russel Petty, Konstantinos Evangelou, Vassilis G. Gorgoulis   +6 more
wiley   +1 more source

The future of technology enhanced active learning – a roadmap [PDF]

, 2008
The notion of active learning refers to the active involvement of learner in the learning process, capturing ideas of learning-by-doing and the fact that active participation and knowledge construction leads to deeper and more sustained learning ...
Kenny, Claire, Pahl, Claus
core  

A literature synthesis of personalised technology-enhanced learning: what works and why [PDF]

, 2018
Personalised learning, having seen both surges and declines in popularity over the past few decades, is once again enjoying a resurgence. Examples include digital resources tailored to a particular learner’s needs, or individual feedback on a student’s ...
*Braun, *Chen, *Crawford, *Glaser, *Jones, *Kingsbury, *Kucirkova, *Loizidou, *Perrotta, *Rienties, *Seldon, *Selwyn, *Sharples, Adams Becker, Bailey, Beetham, Bligh, Bovill, Boys, Broadfoot, Brown, Brown, Caldwell, Campbell, Coffield, Conlan, de Freitas, Dede, Drover, FitzGerald, Green, Guldberg, Hargreaves, Hartley, Higgins, Holmes, Jones, Jordan, Järvelä, Kim, Kinash, Kirschner, Kucirkova, Laurillard, Lei, Martinez, Neves, Paludan, Pearshouse, Sharples, Sunar, Underwood, Underwood, Watkins, Yapp   +54 more
core   +3 more sources

Impact of a senior research thesis on students' perceptions of scientific inquiry in distinct student populations

FEBS Open Bio, EarlyView.
This study addressed how a senior research thesis is perceived by undergraduate students. It assessed students' perception of research skills, epistemological beliefs, and career goals in Biochemistry (science) and BDC (science‐business) students. Completing a thesis improved confidence in research skills, resilience, scientific identity, closed gender‐
Celeste Suart, Haley L. Zubyk, Michelle Ogrodnik, Caitlin E. Mullarkey, Felicia Vulcu   +4 more
wiley   +1 more source