Results 91 to 100 of about 397,549 (315)

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Evaluation Virtual Assistant Chatbot Acceptance with an Unified Technology Acceptance and Use of Technology-Based Model

Journal of Information Systems and Informatics
The virtual assistant chatbot in the MyTelkomsel application is a company's effort to achieve goals and improve business performance. Chatbot as a virtual assistant has advantages and disadvantages.
Radhiya Sabila, Arista Pratama, Eristya Maya Safitri   +2 more
doaj   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

The Impact of Trust on Acceptance of Online Banking

, 2006
Major benefits of Online Banking include for banks cost savings, and for customers convenience. Nevertheless, many people perceive Internet banking as risky. This paper introduces a tentative conceptual framework.
Alsajjan, B, Dennis, C
core  

Mobile library and staff preparedness: Exploring staff competencies using the Unified Theory of Acceptance and Use of Technology model [PDF]

, 2011
Provision of effective service delivery within the mobile environment challenges the way in which libraries operate. Development of staff capability characterises the way in which libraries have responded to the challenge.
Saravani, Sarah-Jane
core  

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

Molecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena, Karin Teien Lande, Eva Diaz, Ana Vilar, Juan Cueva, Efigenia Arias, Victoria Sampayo, Alicia Abalo, Nerea González, Eva Colás, Antonio Gil‐Moreno, Miguel Abal, Gema Moreno‐Bueno, Therese Sørlie, Kristina Lindemann, Laura Muinelo‐Romay   +15 more
wiley   +1 more source

Network effects in Technology Acceptance - Laboratory Evidence, International Conference of Information Systems

, 2008
This research analyzes network effects in technology acceptance, on the hypothesis that the larger is user network, the more likely is technology acceptance.
PONTIGGIA, ANDREA, F. Virili
core  

Assessment of technology acceptance in intensive care units [PDF]

, 2014
The process of deploy a technology in critical services need to be very careful planned and processed. As an example it is the Intensive Care Unit (ICU).
Abelha, António, Portela, Filipe, Machado, José Manuel, Aguiar, Jorge, Santos, Manuel, Rua, Fernando, Silva, Álvaro   +6 more
core  

A structural model of technology acceptance

SA Journal of Industrial Psychology, 2015
Orientation: Enterprise resource systems have not always led to significant organisational enhancement and many projects in which these systems have been implemented turn out to be over budget, not on time and unsuccessful.
Etienne Erasmus, Sebastiaan Rothmann, Chrizanne van Eeden   +2 more
doaj   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source