Results 51 to 60 of about 13,350,536 (306)

Molecular bases of circadian magnesium rhythms across eukaryotes

FEBS Letters, EarlyView.
Circadian rhythms in intracellular [Mg2+] exist across eukaryotic kingdoms. Central roles for Mg2+ in metabolism suggest that Mg2+ rhythms could regulate daily cellular energy and metabolism. In this Perspective paper, we propose that ancestral prokaryotic transport proteins could be responsible for mediating Mg2+ rhythms and posit a feedback model ...
Helen K. Feord, Gerben van Ooijen
wiley   +1 more source

Future-Oriented Technology Assessment☆

, 2017
The purpose of this paper is to reflect onthe concept of Future-Oriented Technology Assessment (FOTA) as a particular form of Technology Assessment (TA) which is focused less on risk assessment and more on the innovation governance with regards to the ...
Łukasz Nazarko
semanticscholar   +1 more source

Persulfate-based Advanced Oxidation: Critical Assessment of Opportunities and Roadblocks.

Environmental Science and Technology, 2020
Reports that promote persulfate-based advanced oxidation process (AOP) as a viable alternative to hydrogen peroxide-based processes have been rapidly accumulating in recent water treatment literature.
Jaesang Lee, U. von Gunten, Jae-Hong Kim
semanticscholar   +1 more source

Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10

FEBS Letters, EarlyView.
Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang, Satoshi Hashimoto, Sota Ito, Chisato Kikuguchi, Miho Hoshi, Kiyoshi Yamaguchi, Yoichi Furukawa, Toru Suzuki, Toshifumi Inada   +8 more
wiley   +1 more source

Neuronal optogenetics as a new topic of technology assessment?

TATuP – Zeitschrift für Technikfolgenabschätzung in Theorie und Praxis
This article is intended as a sketchy reflection on the question of the extent to which neuronal optogenetics could become a future topic of technology assessment (TA).
Hans Zillmann
doaj   +1 more source

Interplay between circadian and other transcription factors—Implications for cycling transcriptome reprogramming

FEBS Letters, EarlyView.
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley   +1 more source

Moulded cast compared with K-wire fixation after manipulation of an acute dorsally displaced distal radius fracture: the DRAFFT 2 RCT

Health Technology Assessment, 2022
Background: Patients with a displaced fracture of the distal radius are frequently offered surgical fixation. Manipulation of the fracture and moulded plaster casting is an alternative treatment that avoids metal implants, but evidence of its ...
Matthew L Costa, Juul Achten, Alexander Ooms, May Ee Png, Jonathan Cook, Melina Dritsaki, Sarah E Lamb, Robin Lerner, Kylea Draper, Marta Campolier, Helen Dakin, Alwin McGibbon, Nicholas Parsons, Helen Hedley, Joseph Dias, the DRAFFT 2 Collaborators   +15 more
doaj   +1 more source

CHANGING HEALTH TECHNOLOGY ASSESSMENT PARADIGMS?

International Journal of Technology Assessment in Health Care, 2016
Objectives: Health technology assessment (HTA) has to innovate to best support changing health system environments and to help provide access to valuable innovation under fiscal constraint.
D. Husereau, C. Henshall, L. Sampietro-Colom, Sarah Thomas   +3 more
semanticscholar   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Public Health Decision-Maker Perspective on Joint Clinical Assessments in Central European EU Member States

Journal of Market Access & Health Policy
The HTA R introduces provisions that may benefit member states, in particular the opportunity to share national or regional assessment reports, cooperate outside of clinical domains, or use the methodological guidelines on a local level for technologies ...
Gergő Merész, Dávid Dankó, Márk Péter Molnár   +2 more
doaj   +1 more source